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Review ArticleReview Article

Pharmacological and Clinical Aspects of Heme Oxygenase

Nader G. Abraham and Attallah Kappas
Pharmacological Reviews March 2008, 60 (1) 79-127; DOI: https://doi.org/10.1124/pr.107.07104
Nader G. Abraham
New York Medical College, Department of Pharmacology and Medicine, Valhalla, New York (N.G.A.); and Rockefeller University Hospital, New York, New York (N.G.A., A.K.)
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Attallah Kappas
New York Medical College, Department of Pharmacology and Medicine, Valhalla, New York (N.G.A.); and Rockefeller University Hospital, New York, New York (N.G.A., A.K.)
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  • Correction to “Pharmacological and Clinical Aspects of Heme Oxygenase” - June 01, 2008

Abstract

This review is intended to stimulate interest in the effect of increased expression of heme oxygenase-1 (HO-1) protein and increased levels of HO activity on normal and pathological states. The HO system includes the heme catabolic pathway, comprising HO and biliverdin reductase, and the products of heme degradation, carbon monoxide (CO), iron, and biliverdin/bilirubin. The role of the HO system in diabetes, inflammation, heart disease, hypertension, neurological disorders, transplantation, endotoxemia and other pathologies is a burgeoning area of research. This review focuses on the clinical potential of increased levels of HO-1 protein and HO activity to ameliorate tissue injury. The use of pharmacological and genetic probes to manipulate HO, leading to new insights into the complex relationship of the HO system with biological and pathological phenomena under investigation, is reviewed. This information is critical in both drug development and the implementation of clinical approaches to moderate and to alleviate the numerous chronic disorders in humans affected by perturbations in the HO system.

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Pharmacological Reviews: 60 (1)
Pharmacological Reviews
Vol. 60, Issue 1
1 Mar 2008
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Review ArticleReview Article

Pharmacological and Clinical Aspects of Heme Oxygenase

Nader G. Abraham and Attallah Kappas
Pharmacological Reviews March 1, 2008, 60 (1) 79-127; DOI: https://doi.org/10.1124/pr.107.07104

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Review ArticleReview Article

Pharmacological and Clinical Aspects of Heme Oxygenase

Nader G. Abraham and Attallah Kappas
Pharmacological Reviews March 1, 2008, 60 (1) 79-127; DOI: https://doi.org/10.1124/pr.107.07104
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  • Article
    • Abstract
    • I. Introduction
    • II. Heme Degradative Pathway
    • III. Pathophysiology of and Clinical Role of Heme Oxygenase-1/Heme Oxygenase-2: Reaction Products
    • IV. Heme Oxygenase in Disease
    • V. Summary
    • Acknowledgments
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    • References
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