Abstract

Historically, calcitonin gene-related peptide (CGRP) receptors have been divided into two classes, CGRP₁ and CGRP₂. After the cloning of calcitonin receptor-like receptor (CLR) and receptor activity-modifying proteins (RAMPs), it became clear that the CGRP₁ receptor was a complex between CLR and RAMP1. It is now apparent that the CGRP₂ receptor phenotype is the result of CGRP acting at receptors for amylin and adrenomedullin. Accordingly, the term “CGRP₂” receptor should no longer be used, and the “CGRP₁” receptor should be known as the “CGRP” receptor.