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Review ArticleReview Article

Orexin/Hypocretin: A Neuropeptide at the Interface of Sleep, Energy Homeostasis, and Reward System

Natsuko Tsujino and Takeshi Sakurai
Pharmacological Reviews June 2009, 61 (2) 162-176; DOI: https://doi.org/10.1124/pr.109.001321
Natsuko Tsujino
Department of Molecular Neuroscience and Integrative Physiology, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan
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Takeshi Sakurai
Department of Molecular Neuroscience and Integrative Physiology, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan
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Pharmacological Reviews: 61 (2)
Pharmacological Reviews
Vol. 61, Issue 2
1 Jun 2009
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Review ArticleReview Article

Orexin/Hypocretin: A Neuropeptide at the Interface of Sleep, Energy Homeostasis, and Reward System

Natsuko Tsujino and Takeshi Sakurai
Pharmacological Reviews June 1, 2009, 61 (2) 162-176; DOI: https://doi.org/10.1124/pr.109.001321

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Review ArticleReview Article

Orexin/Hypocretin: A Neuropeptide at the Interface of Sleep, Energy Homeostasis, and Reward System

Natsuko Tsujino and Takeshi Sakurai
Pharmacological Reviews June 1, 2009, 61 (2) 162-176; DOI: https://doi.org/10.1124/pr.109.001321
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  • Article
    • Abstract
    • I. Introduction
    • II. Orexin and Orexin Receptors
    • III. Input to Orexin Neurons
    • IV. Orexin Deficiency Causes Narcolepsy
    • V. Roles of Orexins in Regulation of Sleep/Wake States
    • VI. Roles of Orexins in Feeding Behavior and Energy Homeostasis
    • VII. Roles of Orexins in Reward Systems
    • VIII. Clinical Implications
    • IX. Conclusion
    • Acknowledgments
    • Footnotes
    • References
  • Figures & Data
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