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Review ArticleReview Article

Orexin/Hypocretin: A Neuropeptide at the Interface of Sleep, Energy Homeostasis, and Reward System

Natsuko Tsujino and Takeshi Sakurai
Pharmacological Reviews June 2009, 61 (2) 162-176; DOI: https://doi.org/10.1124/pr.109.001321
Natsuko Tsujino
Department of Molecular Neuroscience and Integrative Physiology, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan
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Takeshi Sakurai
Department of Molecular Neuroscience and Integrative Physiology, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan
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Article Information

vol. 61 no. 2 162-176
DOI 
https://doi.org/10.1124/pr.109.001321
PubMed 
19549926

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0031-6997
Online ISSN 
1521-0081
History 
  • Published online June 23, 2009.

Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Natsuko Tsujino and
  2. Takeshi Sakurai
  1. Department of Molecular Neuroscience and Integrative Physiology, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan
  1. Address correspondence to: Dr. Takeshi Sakurai, Department of Molecular Neuroscience and Integrative Physiology, Graduate School of Medical Science, Kanazawa University, 13-1 Takaramachi, Kanazawa-shi, Ishikawa 920-8640, Japan. E-mail: tsakurai{at}med.kanazawa-u.ac.jp.
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In this issue

Pharmacological Reviews: 61 (2)
Pharmacological Reviews
Vol. 61, Issue 2
1 Jun 2009
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Review ArticleReview Article

Orexin/Hypocretin: A Neuropeptide at the Interface of Sleep, Energy Homeostasis, and Reward System

Natsuko Tsujino and Takeshi Sakurai
Pharmacological Reviews June 1, 2009, 61 (2) 162-176; DOI: https://doi.org/10.1124/pr.109.001321

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Review ArticleReview Article

Orexin/Hypocretin: A Neuropeptide at the Interface of Sleep, Energy Homeostasis, and Reward System

Natsuko Tsujino and Takeshi Sakurai
Pharmacological Reviews June 1, 2009, 61 (2) 162-176; DOI: https://doi.org/10.1124/pr.109.001321
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  • Article
    • Abstract
    • I. Introduction
    • II. Orexin and Orexin Receptors
    • III. Input to Orexin Neurons
    • IV. Orexin Deficiency Causes Narcolepsy
    • V. Roles of Orexins in Regulation of Sleep/Wake States
    • VI. Roles of Orexins in Feeding Behavior and Energy Homeostasis
    • VII. Roles of Orexins in Reward Systems
    • VIII. Clinical Implications
    • IX. Conclusion
    • Acknowledgments
    • Footnotes
    • References
  • Figures & Data
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