Review ArticleReview Article
Ghrelin Gene Products and the Regulation of Food Intake and Gut Motility
Chih-Yen Chen, Akihiro Asakawa, Mineko Fujimiya, Shou-Dong Lee and Akio Inui
Pharmacological Reviews December 2009, 61 (4) 430-481; DOI: https://doi.org/10.1124/pr.109.001958
Chih-Yen Chen
Faculty of Medicine, National Yang-Ming University School of Medicine, Taipei (C.-Y.C, S.-D.L.), and Division of Gastroenterology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan (C.-Y.C, S.-D.L.); Department of Anatomy, Sapporo Medical University School of Medicine, Sapporo, Hokkaido, Japan (M.F.); and Department of Psychosomatic Internal Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan (A.A., A.I.)
Akihiro Asakawa
Faculty of Medicine, National Yang-Ming University School of Medicine, Taipei (C.-Y.C, S.-D.L.), and Division of Gastroenterology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan (C.-Y.C, S.-D.L.); Department of Anatomy, Sapporo Medical University School of Medicine, Sapporo, Hokkaido, Japan (M.F.); and Department of Psychosomatic Internal Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan (A.A., A.I.)
Mineko Fujimiya
Faculty of Medicine, National Yang-Ming University School of Medicine, Taipei (C.-Y.C, S.-D.L.), and Division of Gastroenterology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan (C.-Y.C, S.-D.L.); Department of Anatomy, Sapporo Medical University School of Medicine, Sapporo, Hokkaido, Japan (M.F.); and Department of Psychosomatic Internal Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan (A.A., A.I.)
Shou-Dong Lee
Faculty of Medicine, National Yang-Ming University School of Medicine, Taipei (C.-Y.C, S.-D.L.), and Division of Gastroenterology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan (C.-Y.C, S.-D.L.); Department of Anatomy, Sapporo Medical University School of Medicine, Sapporo, Hokkaido, Japan (M.F.); and Department of Psychosomatic Internal Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan (A.A., A.I.)
Akio Inui
Faculty of Medicine, National Yang-Ming University School of Medicine, Taipei (C.-Y.C, S.-D.L.), and Division of Gastroenterology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan (C.-Y.C, S.-D.L.); Department of Anatomy, Sapporo Medical University School of Medicine, Sapporo, Hokkaido, Japan (M.F.); and Department of Psychosomatic Internal Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan (A.A., A.I.)
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Review ArticleReview Article
Ghrelin Gene Products and the Regulation of Food Intake and Gut Motility
Chih-Yen Chen, Akihiro Asakawa, Mineko Fujimiya, Shou-Dong Lee and Akio Inui
Pharmacological Reviews December 1, 2009, 61 (4) 430-481; DOI: https://doi.org/10.1124/pr.109.001958
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- Article
- Abstract
- I. Introduction: Discovery of Growth Hormone Secretagogue Receptor, Ghrelin Gene Products (Acyl Ghrelin, Des-Acyl Ghrelin, and Obestatin), and Ghrelin O-acyltransferase
- II. Normal Physiology of Acyl Ghrelin and Regulation of Its Expression and Interactions
- III. Normal Physiology of Des-Acyl Ghrelin and Regulation of Its Expression and Interactions
- IV. Normal Physiology of Obestatin and Regulation of Its Expression and Interactions
- V. Normal Physiology, Expression, and Regulation of Growth Hormone Secretagogue Receptor
- VI. Normal Physiology, Expression, and Regulation of Ghrelin O-acyltransferase
- VII. Pathophysiology of Ghrelin Gene Products in Feeding and Body Weight Regulation
- VIII. Normal Physiology and Pathophysiology of Ghrelin Gene Products in Feeding-Associated Gastrointestinal Motility
- IX. Access of Ghrelin Gene Products to the Central Nervous System: Direct and Indirect Neuroendocrine Pathways
- X. Direct Effects of Ghrelin Gene Products on Other Tissues
- XI. Disturbance of Energy Homeostasis in Various Conditions: Roles of Ghrelin Gene Products in Obesity and Anorexia-Cachexia
- XII. Therapeutic Approaches to Affecting the Ghrelin System: Endogenous Ghrelin Gene Products, Growth Hormone Secretagogue Receptor 1a, and Ghrelin O-acyltransferase
- XIII. Conclusions
- Acknowledgments.
- Footnotes
- References
- Figures & Data
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