Review ArticleReview Article
Oxidation of the Endogenous Cannabinoid Arachidonoyl Ethanolamide by the Cytochrome P450 Monooxygenases: Physiological and Pharmacological Implications
Natasha T. Snider, Vyvyca J. Walker and Paul F. Hollenberg
Pharmacological Reviews March 2010, 62 (1) 136-154; DOI: https://doi.org/10.1124/pr.109.001081
Natasha T. Snider
Departments of Pharmacology (N.T.S., V.J.W., P.F.H.) and Molecular and Integrative Physiology (N.T.S.), University of Michigan Medical School, Ann Arbor, Michigan
Vyvyca J. Walker
Departments of Pharmacology (N.T.S., V.J.W., P.F.H.) and Molecular and Integrative Physiology (N.T.S.), University of Michigan Medical School, Ann Arbor, Michigan
Paul F. Hollenberg
Departments of Pharmacology (N.T.S., V.J.W., P.F.H.) and Molecular and Integrative Physiology (N.T.S.), University of Michigan Medical School, Ann Arbor, Michigan
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Review ArticleReview Article
Oxidation of the Endogenous Cannabinoid Arachidonoyl Ethanolamide by the Cytochrome P450 Monooxygenases: Physiological and Pharmacological Implications
Natasha T. Snider, Vyvyca J. Walker and Paul F. Hollenberg
Pharmacological Reviews March 1, 2010, 62 (1) 136-154; DOI: https://doi.org/10.1124/pr.109.001081
Review ArticleReview Article
Oxidation of the Endogenous Cannabinoid Arachidonoyl Ethanolamide by the Cytochrome P450 Monooxygenases: Physiological and Pharmacological Implications
Natasha T. Snider, Vyvyca J. Walker and Paul F. Hollenberg
Pharmacological Reviews March 1, 2010, 62 (1) 136-154; DOI: https://doi.org/10.1124/pr.109.001081
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- Article
- Abstract
- I. Introduction
- II. Cannabis, the Endocannabinoid System, and Therapeutic Relevance
- III. The Regulation of Cellular and Tissue Concentrations of Anandamide: Synthesis
- IV. The Regulation of Cellular and Tissue Concentrations of Anandamide: Uptake
- V. The Regulation of Cellular and Tissue Concentrations of Anandamide: Degradation
- VI. Oxidative Metabolism of Anandamide
- VII. Anandamide Metabolism by Rodent Cytochrome P450 Enzymes
- VIII. Anandamide Metabolism by Human Cytochrome P450 Enzymes
- IX. Physiological and Pharmacological Relevance of the Cytochrome P450-Mediated Oxidation of Anandamide
- X. Future Directions
- Acknowledgments.
- Footnotes
- References
- Figures & Data
- Info & Metrics
- eLetters
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