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Review ArticleReview Article

Insulin-Like Growth Factor-I Regulation of Immune Function: A Potential Therapeutic Target in Autoimmune Diseases?

Terry J. Smith
Pharmacological Reviews June 2010, 62 (2) 199-236; DOI: https://doi.org/10.1124/pr.109.002469
Terry J. Smith
Division of Molecular Medicine, Department of Medicine, Harbor-UCLA Medical Center, Torrance, California; the David Geffen School of Medicine at UCLA, Los Angeles, California; and Departments of Ophthalmology and Visual Sciences and Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan
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Pharmacological Reviews: 62 (2)
Pharmacological Reviews
Vol. 62, Issue 2
1 Jun 2010
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Review ArticleReview Article

Insulin-Like Growth Factor-I Regulation of Immune Function: A Potential Therapeutic Target in Autoimmune Diseases?

Terry J. Smith
Pharmacological Reviews June 1, 2010, 62 (2) 199-236; DOI: https://doi.org/10.1124/pr.109.002469

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Review ArticleReview Article

Insulin-Like Growth Factor-I Regulation of Immune Function: A Potential Therapeutic Target in Autoimmune Diseases?

Terry J. Smith
Pharmacological Reviews June 1, 2010, 62 (2) 199-236; DOI: https://doi.org/10.1124/pr.109.002469
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  • Article
    • Abstract
    • I. Introduction
    • II. Structure and Biology of Insulin-Like Growth Factor-I, Insulin-Like Growth Factor Receptor, and Insulin-Like Growth Factor-I Binding Proteins
    • III. Emerging Insights into Insulin-Like Growth Factor-I and Insulin-Like Growth Factor-I Receptor: Roles in Immune Integration
    • IV. Impact of Insulin-Like Growth Factor-I and Insulin-Like Growth Factor-I Receptor on Immune Cell Lineages
    • V. Implications of Insulin-Like Growth Factor-I and Insulin-Like Growth Factor-I Receptor in Immune Modulation
    • VI. Insulin-Like Growth Factor-I, Insulin-Like Growth Factor-I Receptor, and Autoimmunity
    • VII. Therapeutic Horizons for Autoimmunity: Focusing on Insulin-Like Growth Factor-I and Insulin-Like Growth Factor-I Receptor
    • VIII. Translational Strategies for Modulation of Insulin-Like Growth Factor-I or Insulin-Like Growth Factor-I Receptor
    • IX. Conclusions
    • Acknowledgments.
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