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Review ArticleReview Article

Targeting Intermediary Metabolism in the Hypothalamus as a Mechanism to Regulate Appetite

Gary D. Lopaschuk, John R. Ussher and Jagdip S. Jaswal
Pharmacological Reviews June 2010, 62 (2) 237-264; DOI: https://doi.org/10.1124/pr.109.002428
Gary D. Lopaschuk
Cardiovascular Research Centre, Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Alberta, Canada
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John R. Ussher
Cardiovascular Research Centre, Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Alberta, Canada
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Jagdip S. Jaswal
Cardiovascular Research Centre, Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Alberta, Canada
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Article Information

vol. 62 no. 2 237-264
DOI 
https://doi.org/10.1124/pr.109.002428
PubMed 
20392806

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0031-6997
Online ISSN 
1521-0081
History 
  • Published online May 14, 2010.

Article Versions

  • Earlier version (April 14, 2010 - 05:14).
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Copyright & Usage 
Copyright © 2010 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Gary D. Lopaschuk,
  2. John R. Ussher, and
  3. Jagdip S. Jaswal
  1. Cardiovascular Research Centre, Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Alberta, Canada
  1. Address correspondence to: Dr. Gary Lopaschuk, 423 Heritage Medical Research Center, University of Alberta, Edmonton, Canada, T6G 2S2. E-mail: gary.lopaschuk{at}ualberta.ca
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Pharmacological Reviews: 62 (2)
Pharmacological Reviews
Vol. 62, Issue 2
1 Jun 2010
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Review ArticleReview Article

Targeting Intermediary Metabolism in the Hypothalamus as a Mechanism to Regulate Appetite

Gary D. Lopaschuk, John R. Ussher and Jagdip S. Jaswal
Pharmacological Reviews June 1, 2010, 62 (2) 237-264; DOI: https://doi.org/10.1124/pr.109.002428

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Review ArticleReview Article

Targeting Intermediary Metabolism in the Hypothalamus as a Mechanism to Regulate Appetite

Gary D. Lopaschuk, John R. Ussher and Jagdip S. Jaswal
Pharmacological Reviews June 1, 2010, 62 (2) 237-264; DOI: https://doi.org/10.1124/pr.109.002428
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  • Article
    • Abstract
    • I. Introduction
    • II. Hypothalamic Metabolism and the Regulation of Appetite
    • III. Signaling Pathways Involved in the Hypothalamic Regulation of Appetite
    • IV. Alterations in Hypothalamic 5′AMP-Activated Protein Kinase and Malonyl CoA That Modify Feeding Behavior and Influence Obesity
    • V. Optimizing Hypothalamic Intermediary Metabolism as a Pharmacological Intervention to Modify Appetite
    • VI. Summary
    • Acknowledgments.
    • Footnotes
    • References
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