Advertisement
Review ArticleReview Article

Seven Transmembrane Receptors as Shapeshifting Proteins: The Impact of Allosteric Modulation and Functional Selectivity on New Drug Discovery

Terry Kenakin and Laurence J. Miller
Pharmacological Reviews June 2010, 62 (2) 265-304; DOI: https://doi.org/10.1124/pr.108.000992

Article Information

vol. 62 no. 2 265-304
DOI 
https://doi.org/10.1124/pr.108.000992
PubMed 
20392808
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0031-6997
Online ISSN 
1521-0081
History 
  • Published online May 14, 2010.

Article Versions

Copyright & Usage 
Copyright © 2010 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Terry Kenakin and
  2. Laurence J. Miller
  1. Molecular Discovery Research, GlaxoSmithKline Research and Development, Research Triangle Park, North Carolina (T.P.K.); and Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Scottsdale, Arizona (L.J.M.)
  1. Address correspondence to: Terry P. Kenakin, GlaxoSmithKline, 5 Moore Drive, Mailtstop V-287, Research Triangle Park, NC 27709. E-mail: terry.p.kenakin{at}gsk.com
View Full Text

Funding

  • National Institutes of Health

    DK32878; DK46577

Statistics from Altmetric.com

Article usage

Article usage: January 2018 to February 2023

AbstractFullPdf
Jan 2018295921
Feb 2018167335
Mar 2018216633
Apr 2018208326
May 2018207426
Jun 201846124
Jul 2018730323
Aug 2018123620
Sep 20181013233
Oct 2018114134
Nov 2018176324
Dec 201870148
Jan 201973377
Feb 2019623610
Mar 2019725211
Apr 2019694916
May 20192235614
Jun 201948259
Jul 201961159
Aug 2019732411
Oct 201957217
Nov 201975165
Dec 201944177
Jan 202042416
Feb 2020179443
Mar 2020123477
May 202097516
Jun 20201304611
Jul 202094477
Aug 20203453
Sep 202068166
Oct 202091169
Nov 20206282
Dec 202083185
Jan 2021705211
Feb 20211095516
Mar 202155226
Apr 2021126122
May 202190235
Jun 202170242
Jul 20216985
Aug 202155337
Sep 202174238
Oct 202172109
Nov 20215593
Dec 202156233
Jan 20224988
Feb 202281118
Mar 20225384
Apr 202268156
May 202254127
Jun 202254105
Jul 2022811710
Aug 202261137
Sep 202260415
Oct 2022382324
Nov 2022639616
Dec 202264169
Jan 202392154
Feb 20231653

Back to top

In this issue

Download PDF
Article Alerts
Email Article
Citation Tools

Review ArticleReview Article

Seven Transmembrane Receptors as Shapeshifting Proteins: The Impact of Allosteric Modulation and Functional Selectivity on New Drug Discovery

Terry Kenakin and Laurence J. Miller
Pharmacological Reviews June 1, 2010, 62 (2) 265-304; DOI: https://doi.org/10.1124/pr.108.000992
del.icio.us logo Digg logo Reddit logo Twitter logo Facebook logo Google logo Mendeley logo

Jump to section

Advertisement