Seven Transmembrane Receptors as Shapeshifting Proteins: The Impact of Allosteric Modulation and Functional Selectivity on New Drug Discovery

Molecular Discovery Research, GlaxoSmithKline Research and Development, Research Triangle Park, North Carolina (T.P.K.); and Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Scottsdale, Arizona (L.J.M.)

Address correspondence to: Terry P. Kenakin, GlaxoSmithKline, 5 Moore Drive, Mailtstop V-287, Research Triangle Park, NC 27709. E-mail: terry.p.kenakin{at}gsk.com

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Funding

National Institutes of Health
DK32878; DK46577

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