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Research ArticleIUPHAR Nomenclature Reports

International Union of Basic and Clinical Pharmacology. LXXV. Nomenclature, Classification, and Pharmacology of G Protein-Coupled Melatonin Receptors

Margarita L. Dubocovich, Philippe Delagrange, Diana N. Krause, David Sugden, Daniel P. Cardinali and James Olcese
Pharmacological Reviews September 2010, 62 (3) 343-380; DOI: https://doi.org/10.1124/pr.110.002832
Margarita L. Dubocovich
Department of Pharmacology and Toxicology, School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, New York (M.L.D.); Department Molecular Pharmacology and Biological Chemistry, Feinberg School of Medicine, Northwestern University, Chicago, Illinois (M.L.D.); Experimental Sciences Department, Institut de Recherches Servier, Suresnes, France (P.D.); Department of Pharmacology, College of Medicine, University of California, Irvine, California (D.N.K.); Division of Reproduction and Endocrinology, School of Biomedical and Health Sciences, King's College London, United Kingdom (D.S.); Department of Teaching & Research, Faculty of Medical Sciences, Pontificia Universidad Católica Argentina, Buenos Aires, Argentina (D.P.C.); and Department of Biomedical Sciences, Florida State University College of Medicine, Tallahassee, Florida (J.O.)
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Philippe Delagrange
Department of Pharmacology and Toxicology, School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, New York (M.L.D.); Department Molecular Pharmacology and Biological Chemistry, Feinberg School of Medicine, Northwestern University, Chicago, Illinois (M.L.D.); Experimental Sciences Department, Institut de Recherches Servier, Suresnes, France (P.D.); Department of Pharmacology, College of Medicine, University of California, Irvine, California (D.N.K.); Division of Reproduction and Endocrinology, School of Biomedical and Health Sciences, King's College London, United Kingdom (D.S.); Department of Teaching & Research, Faculty of Medical Sciences, Pontificia Universidad Católica Argentina, Buenos Aires, Argentina (D.P.C.); and Department of Biomedical Sciences, Florida State University College of Medicine, Tallahassee, Florida (J.O.)
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Diana N. Krause
Department of Pharmacology and Toxicology, School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, New York (M.L.D.); Department Molecular Pharmacology and Biological Chemistry, Feinberg School of Medicine, Northwestern University, Chicago, Illinois (M.L.D.); Experimental Sciences Department, Institut de Recherches Servier, Suresnes, France (P.D.); Department of Pharmacology, College of Medicine, University of California, Irvine, California (D.N.K.); Division of Reproduction and Endocrinology, School of Biomedical and Health Sciences, King's College London, United Kingdom (D.S.); Department of Teaching & Research, Faculty of Medical Sciences, Pontificia Universidad Católica Argentina, Buenos Aires, Argentina (D.P.C.); and Department of Biomedical Sciences, Florida State University College of Medicine, Tallahassee, Florida (J.O.)
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David Sugden
Department of Pharmacology and Toxicology, School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, New York (M.L.D.); Department Molecular Pharmacology and Biological Chemistry, Feinberg School of Medicine, Northwestern University, Chicago, Illinois (M.L.D.); Experimental Sciences Department, Institut de Recherches Servier, Suresnes, France (P.D.); Department of Pharmacology, College of Medicine, University of California, Irvine, California (D.N.K.); Division of Reproduction and Endocrinology, School of Biomedical and Health Sciences, King's College London, United Kingdom (D.S.); Department of Teaching & Research, Faculty of Medical Sciences, Pontificia Universidad Católica Argentina, Buenos Aires, Argentina (D.P.C.); and Department of Biomedical Sciences, Florida State University College of Medicine, Tallahassee, Florida (J.O.)
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Daniel P. Cardinali
Department of Pharmacology and Toxicology, School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, New York (M.L.D.); Department Molecular Pharmacology and Biological Chemistry, Feinberg School of Medicine, Northwestern University, Chicago, Illinois (M.L.D.); Experimental Sciences Department, Institut de Recherches Servier, Suresnes, France (P.D.); Department of Pharmacology, College of Medicine, University of California, Irvine, California (D.N.K.); Division of Reproduction and Endocrinology, School of Biomedical and Health Sciences, King's College London, United Kingdom (D.S.); Department of Teaching & Research, Faculty of Medical Sciences, Pontificia Universidad Católica Argentina, Buenos Aires, Argentina (D.P.C.); and Department of Biomedical Sciences, Florida State University College of Medicine, Tallahassee, Florida (J.O.)
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James Olcese
Department of Pharmacology and Toxicology, School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, New York (M.L.D.); Department Molecular Pharmacology and Biological Chemistry, Feinberg School of Medicine, Northwestern University, Chicago, Illinois (M.L.D.); Experimental Sciences Department, Institut de Recherches Servier, Suresnes, France (P.D.); Department of Pharmacology, College of Medicine, University of California, Irvine, California (D.N.K.); Division of Reproduction and Endocrinology, School of Biomedical and Health Sciences, King's College London, United Kingdom (D.S.); Department of Teaching & Research, Faculty of Medical Sciences, Pontificia Universidad Católica Argentina, Buenos Aires, Argentina (D.P.C.); and Department of Biomedical Sciences, Florida State University College of Medicine, Tallahassee, Florida (J.O.)
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Article Information

vol. 62 no. 3 343-380
DOI 
https://doi.org/10.1124/pr.110.002832
PubMed 
20605968

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0031-6997
Online ISSN 
1521-0081
History 
  • Published online August 17, 2010.

Article Versions

  • Earlier version (July 6, 2010 - 08:02).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2010 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Margarita L. Dubocovich,
  2. Philippe Delagrange,
  3. Diana N. Krause,
  4. David Sugden,
  5. Daniel P. Cardinali, and
  6. James Olcese
  1. Department of Pharmacology and Toxicology, School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, New York (M.L.D.); Department Molecular Pharmacology and Biological Chemistry, Feinberg School of Medicine, Northwestern University, Chicago, Illinois (M.L.D.); Experimental Sciences Department, Institut de Recherches Servier, Suresnes, France (P.D.); Department of Pharmacology, College of Medicine, University of California, Irvine, California (D.N.K.); Division of Reproduction and Endocrinology, School of Biomedical and Health Sciences, King's College London, United Kingdom (D.S.); Department of Teaching & Research, Faculty of Medical Sciences, Pontificia Universidad Católica Argentina, Buenos Aires, Argentina (D.P.C.); and Department of Biomedical Sciences, Florida State University College of Medicine, Tallahassee, Florida (J.O.)
  1. Address correspondence to: Dr. Margarita L. Dubocovich, Department of Pharmacology and Toxicology, 102 Farber Hall, School of Medicine and Biomedical Sciences University at Buffalo State University of New York (SUNY), 3435 Main Street, Buffalo, NY 14214. E-mail: mdubo{at}buffalo.edu
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Pharmacological Reviews: 62 (3)
Pharmacological Reviews
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1 Sep 2010
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Research ArticleIUPHAR Nomenclature Reports

International Union of Basic and Clinical Pharmacology. LXXV. Nomenclature, Classification, and Pharmacology of G Protein-Coupled Melatonin Receptors

Margarita L. Dubocovich, Philippe Delagrange, Diana N. Krause, David Sugden, Daniel P. Cardinali and James Olcese
Pharmacological Reviews September 1, 2010, 62 (3) 343-380; DOI: https://doi.org/10.1124/pr.110.002832

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Research ArticleIUPHAR Nomenclature Reports

International Union of Basic and Clinical Pharmacology. LXXV. Nomenclature, Classification, and Pharmacology of G Protein-Coupled Melatonin Receptors

Margarita L. Dubocovich, Philippe Delagrange, Diana N. Krause, David Sugden, Daniel P. Cardinali and James Olcese
Pharmacological Reviews September 1, 2010, 62 (3) 343-380; DOI: https://doi.org/10.1124/pr.110.002832
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  • Article
    • Abstract
    • I. Introduction
    • II. G Protein-Coupled Melatonin Receptor Family
    • III. Cellular Signaling of MT1 and MT2 Melatonin Receptors
    • IV. MT1 and MT2 Melatonin Receptors: Structure-Activity Relationships and Selective Ligands
    • V. MT1- and MT2-Mediated Functional Responses
    • VI. Melatonin receptors as therapeutic targets
    • VII. Conclusion
    • Acknowledgments.
    • Footnotes
    • References
  • Figures & Data
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