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Research ArticleIUPHAR Nomenclature Reports

International Union of Basic and Clinical Pharmacology. LXXVI. Current Progress in the Mammalian TRP Ion Channel Family

Long-Jun Wu, Tara-Beth Sweet and David E. Clapham
Pharmacological Reviews September 2010, 62 (3) 381-404; DOI: https://doi.org/10.1124/pr.110.002725
Long-Jun Wu
Howard Hughes Medical Institute, Department of Cardiology, Manton Center for Orphan Disease, Children's Hospital Boston and Department of Neurobiology, Harvard Medical School, Boston, Massachusetts
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Tara-Beth Sweet
Howard Hughes Medical Institute, Department of Cardiology, Manton Center for Orphan Disease, Children's Hospital Boston and Department of Neurobiology, Harvard Medical School, Boston, Massachusetts
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David E. Clapham
Howard Hughes Medical Institute, Department of Cardiology, Manton Center for Orphan Disease, Children's Hospital Boston and Department of Neurobiology, Harvard Medical School, Boston, Massachusetts
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    Fig. 1.

    TRPC (canonical) family. A, molecular domains of TRPC channels and their current-voltage relationships. The TRP box is a conserved region in TRPC, TRPV, and TRPM families; its function is unclear, but it may bind PIP2. CIRB refers to a calmodulin/IP3R-binding (CIRB) domain. The EF hand is a helix-loop-helix structural domain found in a large family of calcium-binding proteins. PDZ (postsynaptic density 95/disc-large/zona occludens) is a common protein interaction motif that holds together signaling complexes. In this and the following figures, steady state current-voltage curves are shown. B, results of genetic deletion experiments. The TrpC7(−/−) phenotype has not been reported. TrpC2 is a pseudogene in humans.

  • Fig. 2.
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    Fig. 2.

    TRPV (vanilloid) family. A, molecular domains of TRPV channels and their current-voltage relationships. The ankyrin repeat is an ∼33-residue motif consisting of two α helices separated by loops. This region in TRPV1 binds ATP. B, results of genetic deletion experiments.

  • Fig. 3.
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    Fig. 3.

    TRPM (melastatin) family. A, molecular domains of TRPM channels and their current-voltage relationships. NUDIX is a phosphohydrolase family homologous region in TRPM2 that binds ADP ribose. TRM6 and TRPM7 possess a C-terminal serine/threonine kinase that is similar in structure to protein kinase A. B, results of genetic deletion experiments.

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    Fig. 4.

    TRPA1 (ankyrin repeat), TRPML (mucolipin) and TRPP [polycystic kidney disease 2 (PKD2), also called polycystin 2 (PC2)] channels. A, “distal” TRP molecular domains and their current-voltage relationships. The ER retention signal is a small domain that presumably maintains the channel in the endoplasmic reticulum. Note that the current-voltage relationship for TRPA1 shows decay at positive potentials in most whole-cell recordings and is linear with electrophilic agonist. B, major phenotypes in “distal” TRP channel knockout mice. Note: the PKD1 refers to the 11-TM domain-containing protein of the polycystin 1 family. TRPP (PKD2, polycystin 2, PC2) refers to the 6-TM family of proteins.

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Pharmacological Reviews: 62 (3)
Pharmacological Reviews
Vol. 62, Issue 3
1 Sep 2010
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Research ArticleIUPHAR Nomenclature Reports

International Union of Basic and Clinical Pharmacology. LXXVI. Current Progress in the Mammalian TRP Ion Channel Family

Long-Jun Wu, Tara-Beth Sweet and David E. Clapham
Pharmacological Reviews September 1, 2010, 62 (3) 381-404; DOI: https://doi.org/10.1124/pr.110.002725

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Research ArticleIUPHAR Nomenclature Reports

International Union of Basic and Clinical Pharmacology. LXXVI. Current Progress in the Mammalian TRP Ion Channel Family

Long-Jun Wu, Tara-Beth Sweet and David E. Clapham
Pharmacological Reviews September 1, 2010, 62 (3) 381-404; DOI: https://doi.org/10.1124/pr.110.002725
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  • Article
    • Abstract
    • I. Introduction
    • II. The Transient Receptor Potential (Canonical) Family
    • III. The Transient Receptor Potential (Vanilloid) Family
    • IV. The Transient Receptor Potential (Melastatin) Family
    • V. The Transient Receptor Potential (Ankyrin) Family
    • VI. The Transient Receptor Potential (Mucolipin) Family
    • VII. The Transient Receptor Potential (Polycystin)/Polycystic Kidney Disease 2 Family
    • VIII. Summary
    • Acknowledgments.
    • Footnotes
    • References
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