Article Figures & Data
Figures
- Fig. 1.
TRPC (canonical) family. A, molecular domains of TRPC channels and their current-voltage relationships. The TRP box is a conserved region in TRPC, TRPV, and TRPM families; its function is unclear, but it may bind PIP2. CIRB refers to a calmodulin/IP3R-binding (CIRB) domain. The EF hand is a helix-loop-helix structural domain found in a large family of calcium-binding proteins. PDZ (postsynaptic density 95/disc-large/zona occludens) is a common protein interaction motif that holds together signaling complexes. In this and the following figures, steady state current-voltage curves are shown. B, results of genetic deletion experiments. The TrpC7(−/−) phenotype has not been reported. TrpC2 is a pseudogene in humans.
- Fig. 2.
TRPV (vanilloid) family. A, molecular domains of TRPV channels and their current-voltage relationships. The ankyrin repeat is an ∼33-residue motif consisting of two α helices separated by loops. This region in TRPV1 binds ATP. B, results of genetic deletion experiments.
- Fig. 3.
TRPM (melastatin) family. A, molecular domains of TRPM channels and their current-voltage relationships. NUDIX is a phosphohydrolase family homologous region in TRPM2 that binds ADP ribose. TRM6 and TRPM7 possess a C-terminal serine/threonine kinase that is similar in structure to protein kinase A. B, results of genetic deletion experiments.
- Fig. 4.
TRPA1 (ankyrin repeat), TRPML (mucolipin) and TRPP [polycystic kidney disease 2 (PKD2), also called polycystin 2 (PC2)] channels. A, “distal” TRP molecular domains and their current-voltage relationships. The ER retention signal is a small domain that presumably maintains the channel in the endoplasmic reticulum. Note that the current-voltage relationship for TRPA1 shows decay at positive potentials in most whole-cell recordings and is linear with electrophilic agonist. B, major phenotypes in “distal” TRP channel knockout mice. Note: the PKD1 refers to the 11-TM domain-containing protein of the polycystin 1 family. TRPP (PKD2, polycystin 2, PC2) refers to the 6-TM family of proteins.
In this issue
International Union of Basic and Clinical Pharmacology. LXXVI. Current Progress in the Mammalian TRP Ion Channel Family
Jump to section
- Article
- Abstract
- I. Introduction
- II. The Transient Receptor Potential (Canonical) Family
- III. The Transient Receptor Potential (Vanilloid) Family
- IV. The Transient Receptor Potential (Melastatin) Family
- V. The Transient Receptor Potential (Ankyrin) Family
- VI. The Transient Receptor Potential (Mucolipin) Family
- VII. The Transient Receptor Potential (Polycystin)/Polycystic Kidney Disease 2 Family
- VIII. Summary
- Acknowledgments.
- Footnotes
- References
- Figures & Data
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