Review ArticleReview Article
Glutamate Receptor Ion Channels: Structure, Regulation, and Function
Stephen F. Traynelis, Lonnie P. Wollmuth, Chris J. McBain, Frank S. Menniti, Katie M. Vance, Kevin K. Ogden, Kasper B. Hansen, Hongjie Yuan, Scott J. Myers and Ray Dingledine
David Sibley, ASSOCIATE EDITOR
Pharmacological Reviews September 2010, 62 (3) 405-496; DOI: https://doi.org/10.1124/pr.109.002451
Stephen F. Traynelis
Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia (S.F.T., K.M.V., K.K.O., K.B.H., H.Y., S.J.M., R.D.); Department of Neurobiology and Behavior & Center for Nervous System Disorders, Stony Brook University, Stony Brook, New York (L.P.W.); National Institute of Child Health and Human Development, Bethesda, Maryland (C.J.M.); and cyclicM LLC, Mystic, Connecticut (F.S.M.)
Lonnie P. Wollmuth
Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia (S.F.T., K.M.V., K.K.O., K.B.H., H.Y., S.J.M., R.D.); Department of Neurobiology and Behavior & Center for Nervous System Disorders, Stony Brook University, Stony Brook, New York (L.P.W.); National Institute of Child Health and Human Development, Bethesda, Maryland (C.J.M.); and cyclicM LLC, Mystic, Connecticut (F.S.M.)
Chris J. McBain
Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia (S.F.T., K.M.V., K.K.O., K.B.H., H.Y., S.J.M., R.D.); Department of Neurobiology and Behavior & Center for Nervous System Disorders, Stony Brook University, Stony Brook, New York (L.P.W.); National Institute of Child Health and Human Development, Bethesda, Maryland (C.J.M.); and cyclicM LLC, Mystic, Connecticut (F.S.M.)
Frank S. Menniti
Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia (S.F.T., K.M.V., K.K.O., K.B.H., H.Y., S.J.M., R.D.); Department of Neurobiology and Behavior & Center for Nervous System Disorders, Stony Brook University, Stony Brook, New York (L.P.W.); National Institute of Child Health and Human Development, Bethesda, Maryland (C.J.M.); and cyclicM LLC, Mystic, Connecticut (F.S.M.)
Katie M. Vance
Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia (S.F.T., K.M.V., K.K.O., K.B.H., H.Y., S.J.M., R.D.); Department of Neurobiology and Behavior & Center for Nervous System Disorders, Stony Brook University, Stony Brook, New York (L.P.W.); National Institute of Child Health and Human Development, Bethesda, Maryland (C.J.M.); and cyclicM LLC, Mystic, Connecticut (F.S.M.)
Kevin K. Ogden
Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia (S.F.T., K.M.V., K.K.O., K.B.H., H.Y., S.J.M., R.D.); Department of Neurobiology and Behavior & Center for Nervous System Disorders, Stony Brook University, Stony Brook, New York (L.P.W.); National Institute of Child Health and Human Development, Bethesda, Maryland (C.J.M.); and cyclicM LLC, Mystic, Connecticut (F.S.M.)
Kasper B. Hansen
Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia (S.F.T., K.M.V., K.K.O., K.B.H., H.Y., S.J.M., R.D.); Department of Neurobiology and Behavior & Center for Nervous System Disorders, Stony Brook University, Stony Brook, New York (L.P.W.); National Institute of Child Health and Human Development, Bethesda, Maryland (C.J.M.); and cyclicM LLC, Mystic, Connecticut (F.S.M.)
Hongjie Yuan
Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia (S.F.T., K.M.V., K.K.O., K.B.H., H.Y., S.J.M., R.D.); Department of Neurobiology and Behavior & Center for Nervous System Disorders, Stony Brook University, Stony Brook, New York (L.P.W.); National Institute of Child Health and Human Development, Bethesda, Maryland (C.J.M.); and cyclicM LLC, Mystic, Connecticut (F.S.M.)
Scott J. Myers
Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia (S.F.T., K.M.V., K.K.O., K.B.H., H.Y., S.J.M., R.D.); Department of Neurobiology and Behavior & Center for Nervous System Disorders, Stony Brook University, Stony Brook, New York (L.P.W.); National Institute of Child Health and Human Development, Bethesda, Maryland (C.J.M.); and cyclicM LLC, Mystic, Connecticut (F.S.M.)
Ray Dingledine
Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia (S.F.T., K.M.V., K.K.O., K.B.H., H.Y., S.J.M., R.D.); Department of Neurobiology and Behavior & Center for Nervous System Disorders, Stony Brook University, Stony Brook, New York (L.P.W.); National Institute of Child Health and Human Development, Bethesda, Maryland (C.J.M.); and cyclicM LLC, Mystic, Connecticut (F.S.M.)
David Sibley
Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia (S.F.T., K.M.V., K.K.O., K.B.H., H.Y., S.J.M., R.D.); Department of Neurobiology and Behavior & Center for Nervous System Disorders, Stony Brook University, Stony Brook, New York (L.P.W.); National Institute of Child Health and Human Development, Bethesda, Maryland (C.J.M.); and cyclicM LLC, Mystic, Connecticut (F.S.M.)
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In this issue
Review ArticleReview Article
Glutamate Receptor Ion Channels: Structure, Regulation, and Function
Stephen F. Traynelis, Lonnie P. Wollmuth, Chris J. McBain, Frank S. Menniti, Katie M. Vance, Kevin K. Ogden, Kasper B. Hansen, Hongjie Yuan, Scott J. Myers and Ray Dingledine
Pharmacological Reviews September 1, 2010, 62 (3) 405-496; DOI: https://doi.org/10.1124/pr.109.002451
Review ArticleReview Article
Glutamate Receptor Ion Channels: Structure, Regulation, and Function
Stephen F. Traynelis, Lonnie P. Wollmuth, Chris J. McBain, Frank S. Menniti, Katie M. Vance, Kevin K. Ogden, Kasper B. Hansen, Hongjie Yuan, Scott J. Myers and Ray Dingledine
Pharmacological Reviews September 1, 2010, 62 (3) 405-496; DOI: https://doi.org/10.1124/pr.109.002451
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- Article
- Abstract
- I. Introduction and Nomenclature
- II. Structure
- III. Regulation of Transcription and Translation
- IV. Post-Translational Regulation
- V. Agonist and Antagonist Pharmacology
- VI. Allosteric Regulation
- VII. Molecular Determinants of Gating
- VIII. Molecular Determinants of Ion Permeation and Block
- IX. Role in Synaptic Function and Plasticity
- X. Therapeutic Potential
- XI. Conclusions
- Acknowledgments.
- Footnotes
- References
- Figures & Data
- Info & Metrics
- eLetters
- PDF + SI
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