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Frequent Deregulations in the Hedgehog Signaling Network and Cross-Talks with the Epidermal Growth Factor Receptor Pathway Involved in Cancer Progression and Targeted Therapies
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- Article
- Abstract
- I. Introduction
- II. The Hedgehog Signal Transduction Pathway and Regulatory Mechanisms
- III. Critical Functions of the Hedgehog Signaling Pathway during Embryonic and Postnatal Development and Adult Life and Their Therapeutic Implications
- IV. Critical Functions of the Hedgehog Signaling Pathway in the Malignant Transformation of Cancer- and Metastasis-Initiating Cells and Their Progenies
- V. Targeted Therapies
- VI. Conclusions and Future Directions
- Acknowledgments.
- Footnotes
- References
- Figures & Data
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- eLetters
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