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Review ArticleReview Article

Frequent Deregulations in the Hedgehog Signaling Network and Cross-Talks with the Epidermal Growth Factor Receptor Pathway Involved in Cancer Progression and Targeted Therapies

Murielle Mimeault and Surinder K. Batra
David Sibley, ASSOCIATE EDITOR
Pharmacological Reviews September 2010, 62 (3) 497-524; DOI: https://doi.org/10.1124/pr.109.002329
Murielle Mimeault
Department of Biochemistry and Molecular Biology, Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska
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Surinder K. Batra
Department of Biochemistry and Molecular Biology, Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska
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David Sibley
Department of Biochemistry and Molecular Biology, Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska
Roles: ASSOCIATE EDITOR
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Pharmacological Reviews: 62 (3)
Pharmacological Reviews
Vol. 62, Issue 3
1 Sep 2010
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Review ArticleReview Article

Frequent Deregulations in the Hedgehog Signaling Network and Cross-Talks with the Epidermal Growth Factor Receptor Pathway Involved in Cancer Progression and Targeted Therapies

Murielle Mimeault and Surinder K. Batra
Pharmacological Reviews September 1, 2010, 62 (3) 497-524; DOI: https://doi.org/10.1124/pr.109.002329

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Review ArticleReview Article

Frequent Deregulations in the Hedgehog Signaling Network and Cross-Talks with the Epidermal Growth Factor Receptor Pathway Involved in Cancer Progression and Targeted Therapies

Murielle Mimeault and Surinder K. Batra
Pharmacological Reviews September 1, 2010, 62 (3) 497-524; DOI: https://doi.org/10.1124/pr.109.002329
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  • Article
    • Abstract
    • I. Introduction
    • II. The Hedgehog Signal Transduction Pathway and Regulatory Mechanisms
    • III. Critical Functions of the Hedgehog Signaling Pathway during Embryonic and Postnatal Development and Adult Life and Their Therapeutic Implications
    • IV. Critical Functions of the Hedgehog Signaling Pathway in the Malignant Transformation of Cancer- and Metastasis-Initiating Cells and Their Progenies
    • V. Targeted Therapies
    • VI. Conclusions and Future Directions
    • Acknowledgments.
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