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Review ArticleReview Article

Allosteric Modulation of Family C G-Protein-Coupled Receptors: from Molecular Insights to Therapeutic Perspectives

Stephan Urwyler
David R. Sibley, ASSOCIATE EDITOR
Pharmacological Reviews March 2011, 63 (1) 59-126; DOI: https://doi.org/10.1124/pr.109.002501
Stephan Urwyler
Department of Chemistry and Biochemistry, University of Berne, Berne, Switzerland
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David R. Sibley
Department of Chemistry and Biochemistry, University of Berne, Berne, Switzerland
Roles: ASSOCIATE EDITOR
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Article Information

vol. 63 no. 1 59-126
DOI 
https://doi.org/10.1124/pr.109.002501
PubMed 
21228259

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0031-6997
Online ISSN 
1521-0081
History 
  • Published online February 15, 2011.

Article Versions

  • Earlier version (January 12, 2011 - 12:02).
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© 2011 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Stephan Urwyler
  1. Department of Chemistry and Biochemistry, University of Berne, Berne, Switzerland
  1. David R. Sibley, ASSOCIATE EDITOR
  1. Address correspondence to:
    Dr. Stephan Urwyler, Department of Chemistry and Biochemistry, University of Berne, P/A Weissensteinweg 3, CH-3303 Jegenstorf, Switzerland. E-mail: stephan.urwyler{at}ioc.unibe.ch
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Pharmacological Reviews: 63 (1)
Pharmacological Reviews
Vol. 63, Issue 1
1 Mar 2011
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Review ArticleReview Article

Allosteric Modulation of Family C G-Protein-Coupled Receptors: from Molecular Insights to Therapeutic Perspectives

Stephan Urwyler
Pharmacological Reviews March 1, 2011, 63 (1) 59-126; DOI: https://doi.org/10.1124/pr.109.002501

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Review ArticleReview Article

Allosteric Modulation of Family C G-Protein-Coupled Receptors: from Molecular Insights to Therapeutic Perspectives

Stephan Urwyler
Pharmacological Reviews March 1, 2011, 63 (1) 59-126; DOI: https://doi.org/10.1124/pr.109.002501
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  • Article
    • Abstract
    • I. Introduction
    • II. Allosteric Ligands for Taste Receptors: Not Only the Proof of Concept
    • III. Allosteric Modulators Allow for Subtype Selectivity among Multiple Metabotropic Glutamate Receptors
    • IV. GABAB Receptor Function Involves Allosteric Interactions across a Heterodimer
    • V. Allosteric Modulators of the Calcium-Sensing Receptor: the First Clinical Success
    • Authorship Contributions
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