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Review ArticleReview Article

Pharmacogenetics, Pharmacogenomics, and Individualized Medicine

Qiang Ma and Anthony Y. H. Lu
David R. Sibley, ASSOCIATE EDITOR
Pharmacological Reviews June 2011, 63 (2) 437-459; DOI: https://doi.org/10.1124/pr.110.003533
Qiang Ma
Receptor Biology Laboratory, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia (Q.M.); and Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, New Jersey (A.Y.H.L.)
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Anthony Y. H. Lu
Receptor Biology Laboratory, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia (Q.M.); and Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, New Jersey (A.Y.H.L.)
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David R. Sibley
Receptor Biology Laboratory, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia (Q.M.); and Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, New Jersey (A.Y.H.L.)
Roles: ASSOCIATE EDITOR
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Article Information

vol. 63 no. 2 437-459
DOI 
https://doi.org/10.1124/pr.110.003533
PubMed 
21436344

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0031-6997
Online ISSN 
1521-0081
History 
  • Published online April 26, 2011.

Article Versions

  • Earlier version (March 24, 2011 - 08:08).
  • You are viewing the most recent version of this article.
Copyright & Usage 
U.S. Government work not protected by U.S. copyright

Author Information

  1. Qiang Ma and
  2. Anthony Y. H. Lu
  1. Receptor Biology Laboratory, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia (Q.M.); and Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, New Jersey (A.Y.H.L.)
  1. David R. Sibley, ASSOCIATE EDITOR
  1. Address correspondence to:
    Q. Ma, Receptor Biology Laboratory, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 1095 Willowdale Rd., Morgantown, WV 26505. E-mail: qam1{at}cdc.gov
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Pharmacological Reviews: 63 (2)
Pharmacological Reviews
Vol. 63, Issue 2
1 Jun 2011
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Review ArticleReview Article

Pharmacogenetics, Pharmacogenomics, and Individualized Medicine

Qiang Ma and Anthony Y. H. Lu
Pharmacological Reviews June 1, 2011, 63 (2) 437-459; DOI: https://doi.org/10.1124/pr.110.003533

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Review ArticleReview Article

Pharmacogenetics, Pharmacogenomics, and Individualized Medicine

Qiang Ma and Anthony Y. H. Lu
Pharmacological Reviews June 1, 2011, 63 (2) 437-459; DOI: https://doi.org/10.1124/pr.110.003533
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  • Article
    • Abstract
    • I. Introduction
    • II. Drug Response and Inheritance
    • III. Genetic Polymorphisms of Drug Targets
    • IV. Genetic Polymorphisms of Drug-Metabolizing Enzymes
    • V. Genetic Polymorphisms of Drug Transporters
    • VI. Genetic Variables Indirectly Affecting Drug Response
    • VII. Genetic Variables Affecting Adverse Drug Reactions
    • VIII. Translating Pharmacogenomics into Clinics: Individualized Medicine
    • IX. Pharmacogenomics in Drug Development
    • X. Perspectives and Conclusions
    • Acknowledgment
    • Authorship Contributions
    • Footnotes
    • References
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