Table of Contents

Review Articles

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  SLC6 Neurotransmitter Transporters: Structure, Function, and Regulation

  Anders S. Kristensen, Jacob Andersen, Trine N. Jørgensen, Lena Sørensen, Jacob Eriksen, Claus J. Loland, Kristian Strømgaard and Ulrik Gether

  Ulf Simonsen, ASSOCIATE EDITOR

  Pharmacological Reviews September 2011, 63 (3) 585-640; DOI: https://doi.org/10.1124/pr.108.000869
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  Activation and Regulation of Purinergic P2X Receptor Channels

  Claudio Coddou, Zonghe Yan, Tomas Obsil, J. Pablo Huidobro-Toro and Stanko S. Stojilkovic

  David R. Sibley, ASSOCIATE EDITOR

  Pharmacological Reviews September 2011, 63 (3) 641-683; DOI: https://doi.org/10.1124/pr.110.003129
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  Orphans in the Human Cytochrome P450 Superfamily: Approaches to Discovering Functions and Relevance in Pharmacology

  F. Peter Guengerich and Qian Cheng

  Qiang Ma, ASSOCIATE EDITOR

  Pharmacological Reviews September 2011, 63 (3) 684-699; DOI: https://doi.org/10.1124/pr.110.003525
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  Endoplasmic Reticulum Ca²⁺ Handling in Excitable Cells in Health and Disease

  Grace E. Stutzmann and Mark P. Mattson

  David R. Sibley, ASSOCIATE EDITOR

  Pharmacological Reviews September 2011, 63 (3) 700-727; DOI: https://doi.org/10.1124/pr.110.003814
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  Regulators of G-Protein Signaling and Their Gα Substrates: Promises and Challenges in Their Use as Drug Discovery Targets

  Adam J. Kimple, Dustin E. Bosch, Patrick M. Giguère and David P. Siderovski

  Arthur Christopoulos, ASSOCIATE EDITOR

  Pharmacological Reviews September 2011, 63 (3) 728-749; DOI: https://doi.org/10.1124/pr.110.003038
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  Prodrugs—from Serendipity to Rational Design

  Kristiina M. Huttunen, Hannu Raunio and Jarkko Rautio

  Markku Koulu, ASSOCIATE EDITOR

  Pharmacological Reviews September 2011, 63 (3) 750-771; DOI: https://doi.org/10.1124/pr.110.003459
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  Exploring the Neuroimmunopharmacology of Opioids: An Integrative Review of Mechanisms of Central Immune Signaling and Their Implications for Opioid Analgesia

  Mark R. Hutchinson, Yehuda Shavit, Peter M. Grace, Kenner C. Rice, Steven F. Maier and Linda R. Watkins

  Eric L. Barker, ASSOCIATE EDITOR

  Pharmacological Reviews September 2011, 63 (3) 772-810; DOI: https://doi.org/10.1124/pr.110.004135