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Review ArticleReview Article

SLC6 Neurotransmitter Transporters: Structure, Function, and Regulation

Anders S. Kristensen, Jacob Andersen, Trine N. Jørgensen, Lena Sørensen, Jacob Eriksen, Claus J. Loland, Kristian Strømgaard and Ulrik Gether
Ulf Simonsen, ASSOCIATE EDITOR
Pharmacological Reviews September 2011, 63 (3) 585-640; DOI: https://doi.org/10.1124/pr.108.000869
Anders S. Kristensen
Department of Medicinal Chemistry, Faculty of Pharmaceutical Sciences (A.S.K., J.A., L.S., K.S.), and Molecular Neuropharmacology Laboratory, Department of Neuroscience and Pharmacology, Faculty of Health Sciences, Panum Institute (T.N.J., J.E., C.J.L., U.G.), University of Copenhagen, Copenhagen, Denmark
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Jacob Andersen
Department of Medicinal Chemistry, Faculty of Pharmaceutical Sciences (A.S.K., J.A., L.S., K.S.), and Molecular Neuropharmacology Laboratory, Department of Neuroscience and Pharmacology, Faculty of Health Sciences, Panum Institute (T.N.J., J.E., C.J.L., U.G.), University of Copenhagen, Copenhagen, Denmark
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Trine N. Jørgensen
Department of Medicinal Chemistry, Faculty of Pharmaceutical Sciences (A.S.K., J.A., L.S., K.S.), and Molecular Neuropharmacology Laboratory, Department of Neuroscience and Pharmacology, Faculty of Health Sciences, Panum Institute (T.N.J., J.E., C.J.L., U.G.), University of Copenhagen, Copenhagen, Denmark
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Lena Sørensen
Department of Medicinal Chemistry, Faculty of Pharmaceutical Sciences (A.S.K., J.A., L.S., K.S.), and Molecular Neuropharmacology Laboratory, Department of Neuroscience and Pharmacology, Faculty of Health Sciences, Panum Institute (T.N.J., J.E., C.J.L., U.G.), University of Copenhagen, Copenhagen, Denmark
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Jacob Eriksen
Department of Medicinal Chemistry, Faculty of Pharmaceutical Sciences (A.S.K., J.A., L.S., K.S.), and Molecular Neuropharmacology Laboratory, Department of Neuroscience and Pharmacology, Faculty of Health Sciences, Panum Institute (T.N.J., J.E., C.J.L., U.G.), University of Copenhagen, Copenhagen, Denmark
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Claus J. Loland
Department of Medicinal Chemistry, Faculty of Pharmaceutical Sciences (A.S.K., J.A., L.S., K.S.), and Molecular Neuropharmacology Laboratory, Department of Neuroscience and Pharmacology, Faculty of Health Sciences, Panum Institute (T.N.J., J.E., C.J.L., U.G.), University of Copenhagen, Copenhagen, Denmark
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Kristian Strømgaard
Department of Medicinal Chemistry, Faculty of Pharmaceutical Sciences (A.S.K., J.A., L.S., K.S.), and Molecular Neuropharmacology Laboratory, Department of Neuroscience and Pharmacology, Faculty of Health Sciences, Panum Institute (T.N.J., J.E., C.J.L., U.G.), University of Copenhagen, Copenhagen, Denmark
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Ulrik Gether
Department of Medicinal Chemistry, Faculty of Pharmaceutical Sciences (A.S.K., J.A., L.S., K.S.), and Molecular Neuropharmacology Laboratory, Department of Neuroscience and Pharmacology, Faculty of Health Sciences, Panum Institute (T.N.J., J.E., C.J.L., U.G.), University of Copenhagen, Copenhagen, Denmark
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Ulf Simonsen
Department of Medicinal Chemistry, Faculty of Pharmaceutical Sciences (A.S.K., J.A., L.S., K.S.), and Molecular Neuropharmacology Laboratory, Department of Neuroscience and Pharmacology, Faculty of Health Sciences, Panum Institute (T.N.J., J.E., C.J.L., U.G.), University of Copenhagen, Copenhagen, Denmark
Roles: ASSOCIATE EDITOR
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Article Information

vol. 63 no. 3 585-640
DOI 
https://doi.org/10.1124/pr.108.000869
PubMed 
21752877

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0031-6997
Online ISSN 
1521-0081
History 
  • Published online July 19, 2011.

Article Versions

  • Earlier version (July 13, 2011 - 05:43).
  • You are viewing the most recent version of this article.
Copyright & Usage 
© 2011 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Anders S. Kristensen,
  2. Jacob Andersen,
  3. Trine N. Jørgensen,
  4. Lena Sørensen,
  5. Jacob Eriksen,
  6. Claus J. Loland,
  7. Kristian Strømgaard, and
  8. Ulrik Gether
  1. Department of Medicinal Chemistry, Faculty of Pharmaceutical Sciences (A.S.K., J.A., L.S., K.S.), and Molecular Neuropharmacology Laboratory, Department of Neuroscience and Pharmacology, Faculty of Health Sciences, Panum Institute (T.N.J., J.E., C.J.L., U.G.), University of Copenhagen, Copenhagen, Denmark
  1. Ulf Simonsen, ASSOCIATE EDITOR
  1. Address correspondence to:
    Anders S. Kristensen, Department of Medicinal Chemistry, University of Copenhagen, Copenhagen, Denmark. E-mail: ask{at}farma.ku.dk
  2. U.G. may be considered a co-corresponding author: Department of Neuroscience and Pharmacology, Panum Institute, University of Copenhagen, Copenhagen, Denmark. E-mail: gether{at}sund.ku.dk
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Pharmacological Reviews: 63 (3)
Pharmacological Reviews
Vol. 63, Issue 3
1 Sep 2011
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Review ArticleReview Article

SLC6 Neurotransmitter Transporters: Structure, Function, and Regulation

Anders S. Kristensen, Jacob Andersen, Trine N. Jørgensen, Lena Sørensen, Jacob Eriksen, Claus J. Loland, Kristian Strømgaard and Ulrik Gether
Pharmacological Reviews September 1, 2011, 63 (3) 585-640; DOI: https://doi.org/10.1124/pr.108.000869

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Review ArticleReview Article

SLC6 Neurotransmitter Transporters: Structure, Function, and Regulation

Anders S. Kristensen, Jacob Andersen, Trine N. Jørgensen, Lena Sørensen, Jacob Eriksen, Claus J. Loland, Kristian Strømgaard and Ulrik Gether
Pharmacological Reviews September 1, 2011, 63 (3) 585-640; DOI: https://doi.org/10.1124/pr.108.000869
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  • Article
    • Abstract
    • I. Introduction
    • II. Structure and Transport Mechanism
    • III. Pharmacology
    • IV. Physiology and Pathophysiology
    • V. Cellular Regulation
    • VI. Therapeutic Applications of Solute Carrier 6 Neurotransmitter Transporter Drugs
    • VII. Conclusions and Outlook
    • Acknowledgments
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