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Review ArticleReview Article

Regulators of G-Protein Signaling and Their Gα Substrates: Promises and Challenges in Their Use as Drug Discovery Targets

Adam J. Kimple, Dustin E. Bosch, Patrick M. Giguère and David P. Siderovski
Arthur Christopoulos, ASSOCIATE EDITOR
Pharmacological Reviews September 2011, 63 (3) 728-749; DOI: https://doi.org/10.1124/pr.110.003038
Adam J. Kimple
Department of Pharmacology, UNC Neuroscience Center, and Lineberger Comprehensive Cancer Center, the University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina
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Dustin E. Bosch
Department of Pharmacology, UNC Neuroscience Center, and Lineberger Comprehensive Cancer Center, the University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina
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Patrick M. Giguère
Department of Pharmacology, UNC Neuroscience Center, and Lineberger Comprehensive Cancer Center, the University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina
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David P. Siderovski
Department of Pharmacology, UNC Neuroscience Center, and Lineberger Comprehensive Cancer Center, the University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina
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Arthur Christopoulos
Department of Pharmacology, UNC Neuroscience Center, and Lineberger Comprehensive Cancer Center, the University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina
Roles: ASSOCIATE EDITOR
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Article Information

vol. 63 no. 3 728-749
DOI 
https://doi.org/10.1124/pr.110.003038
PubMed 
21737532

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0031-6997
Online ISSN 
1521-0081
History 
  • Published online July 19, 2011.

Article Versions

  • Earlier version (July 7, 2011 - 07:49).
  • You are viewing the most recent version of this article.
Copyright & Usage 
© 2011 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Adam J. Kimple,
  2. Dustin E. Bosch,
  3. Patrick M. Giguère, and
  4. David P. Siderovski
  1. Department of Pharmacology, UNC Neuroscience Center, and Lineberger Comprehensive Cancer Center, the University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina
  1. Arthur Christopoulos, ASSOCIATE EDITOR
  1. Address correspondence to:
    Dr. David P. Siderovski, Department of Pharmacology, UNC School of Medicine, University of North Carolina at Chapel Hill, 4073 Genetic Medicine Bldg., CB#7365, 120 Mason Farm Road, Suite 4010, Chapel Hill, NC 27599-7365. E-mail: dsiderov{at}med.unc.edu
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Funding

  • National Institutes of Health

    R03-DA030555; R01-GM062338; R01-GM074268; R01-GM082892; T32-GM008719; T32-GM007040; F30-MH074266

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Pharmacological Reviews: 63 (3)
Pharmacological Reviews
Vol. 63, Issue 3
1 Sep 2011
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Review ArticleReview Article

Regulators of G-Protein Signaling and Their Gα Substrates: Promises and Challenges in Their Use as Drug Discovery Targets

Adam J. Kimple, Dustin E. Bosch, Patrick M. Giguère and David P. Siderovski
Pharmacological Reviews September 1, 2011, 63 (3) 728-749; DOI: https://doi.org/10.1124/pr.110.003038

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Review ArticleReview Article

Regulators of G-Protein Signaling and Their Gα Substrates: Promises and Challenges in Their Use as Drug Discovery Targets

Adam J. Kimple, Dustin E. Bosch, Patrick M. Giguère and David P. Siderovski
Pharmacological Reviews September 1, 2011, 63 (3) 728-749; DOI: https://doi.org/10.1124/pr.110.003038
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  • Article
    • Abstract
    • I. Introduction
    • II. Selected Functional Vignettes among the Complement of Regulators of G-Protein Signaling
    • III. Pursuing Chemical Probes for Regulators of G-Protein Signaling GTPase-Accelerating Protein Activity
    • IV. Activated Gαq/11 Point Mutants as Targets for Ocular Melanoma Therapeutic Strategies
    • Acknowledgments
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