Review ArticleReview Article
Regulators of G-Protein Signaling and Their Gα Substrates: Promises and Challenges in Their Use as Drug Discovery Targets
Adam J. Kimple, Dustin E. Bosch, Patrick M. Giguère and David P. Siderovski
Arthur Christopoulos, ASSOCIATE EDITOR, Department of Pharmacology, UNC Neuroscience Center, and Lineberger Comprehensive Cancer Center, the University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina
Pharmacological Reviews September 2011, 63 (3) 728-749; DOI: https://doi.org/10.1124/pr.110.003038
Adam J. Kimple
Department of Pharmacology, UNC Neuroscience Center, and Lineberger Comprehensive Cancer Center, the University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina
Dustin E. Bosch
Department of Pharmacology, UNC Neuroscience Center, and Lineberger Comprehensive Cancer Center, the University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina
Patrick M. Giguère
Department of Pharmacology, UNC Neuroscience Center, and Lineberger Comprehensive Cancer Center, the University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina
David P. Siderovski
Department of Pharmacology, UNC Neuroscience Center, and Lineberger Comprehensive Cancer Center, the University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina
Arthur Christopoulos
Department of Pharmacology, UNC Neuroscience Center, and Lineberger Comprehensive Cancer Center, the University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina
Roles: ASSOCIATE EDITOR
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In this issue
Review ArticleReview Article
Regulators of G-Protein Signaling and Their Gα Substrates: Promises and Challenges in Their Use as Drug Discovery Targets
Adam J. Kimple, Dustin E. Bosch, Patrick M. Giguère and David P. Siderovski
Pharmacological Reviews September 1, 2011, 63 (3) 728-749; DOI: https://doi.org/10.1124/pr.110.003038
Review ArticleReview Article
Regulators of G-Protein Signaling and Their Gα Substrates: Promises and Challenges in Their Use as Drug Discovery Targets
Adam J. Kimple, Dustin E. Bosch, Patrick M. Giguère and David P. Siderovski
Pharmacological Reviews September 1, 2011, 63 (3) 728-749; DOI: https://doi.org/10.1124/pr.110.003038
Jump to section
- Article
- Abstract
- I. Introduction
- II. Selected Functional Vignettes among the Complement of Regulators of G-Protein Signaling
- III. Pursuing Chemical Probes for Regulators of G-Protein Signaling GTPase-Accelerating Protein Activity
- IV. Activated Gαq/11 Point Mutants as Targets for Ocular Melanoma Therapeutic Strategies
- Acknowledgments
- Authorship Contributions
- Footnotes
- References
- Figures & Data
- Info & Metrics
- eLetters
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