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Review ArticleReview Article

Exploring the Neuroimmunopharmacology of Opioids: An Integrative Review of Mechanisms of Central Immune Signaling and Their Implications for Opioid Analgesia

Mark R. Hutchinson, Yehuda Shavit, Peter M. Grace, Kenner C. Rice, Steven F. Maier and Linda R. Watkins
Eric L. Barker, ASSOCIATE EDITOR
Pharmacological Reviews September 2011, 63 (3) 772-810; DOI: https://doi.org/10.1124/pr.110.004135
Mark R. Hutchinson
Disciplines of Pharmacology (M.R.H., P.M.G.) and Physiology (M.R.H.), School of Medical Science, University of Adelaide, South Australia, Australia; Department of Psychology and Neuroscience, University of Colorado at Boulder, Boulder, Colorado (M.R.H., S.F.M., L.R.W.); Department of Psychology, Hebrew University of Jerusalem, Jerusalem, Israel (Y.S.); and Chemical Biology Research Branch, National Institute on Drug Abuse and National Institute on Alcohol Abuse and Alcoholism, Rockville, Maryland (K.C.R.)
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Yehuda Shavit
Disciplines of Pharmacology (M.R.H., P.M.G.) and Physiology (M.R.H.), School of Medical Science, University of Adelaide, South Australia, Australia; Department of Psychology and Neuroscience, University of Colorado at Boulder, Boulder, Colorado (M.R.H., S.F.M., L.R.W.); Department of Psychology, Hebrew University of Jerusalem, Jerusalem, Israel (Y.S.); and Chemical Biology Research Branch, National Institute on Drug Abuse and National Institute on Alcohol Abuse and Alcoholism, Rockville, Maryland (K.C.R.)
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Peter M. Grace
Disciplines of Pharmacology (M.R.H., P.M.G.) and Physiology (M.R.H.), School of Medical Science, University of Adelaide, South Australia, Australia; Department of Psychology and Neuroscience, University of Colorado at Boulder, Boulder, Colorado (M.R.H., S.F.M., L.R.W.); Department of Psychology, Hebrew University of Jerusalem, Jerusalem, Israel (Y.S.); and Chemical Biology Research Branch, National Institute on Drug Abuse and National Institute on Alcohol Abuse and Alcoholism, Rockville, Maryland (K.C.R.)
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Kenner C. Rice
Disciplines of Pharmacology (M.R.H., P.M.G.) and Physiology (M.R.H.), School of Medical Science, University of Adelaide, South Australia, Australia; Department of Psychology and Neuroscience, University of Colorado at Boulder, Boulder, Colorado (M.R.H., S.F.M., L.R.W.); Department of Psychology, Hebrew University of Jerusalem, Jerusalem, Israel (Y.S.); and Chemical Biology Research Branch, National Institute on Drug Abuse and National Institute on Alcohol Abuse and Alcoholism, Rockville, Maryland (K.C.R.)
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Steven F. Maier
Disciplines of Pharmacology (M.R.H., P.M.G.) and Physiology (M.R.H.), School of Medical Science, University of Adelaide, South Australia, Australia; Department of Psychology and Neuroscience, University of Colorado at Boulder, Boulder, Colorado (M.R.H., S.F.M., L.R.W.); Department of Psychology, Hebrew University of Jerusalem, Jerusalem, Israel (Y.S.); and Chemical Biology Research Branch, National Institute on Drug Abuse and National Institute on Alcohol Abuse and Alcoholism, Rockville, Maryland (K.C.R.)
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Linda R. Watkins
Disciplines of Pharmacology (M.R.H., P.M.G.) and Physiology (M.R.H.), School of Medical Science, University of Adelaide, South Australia, Australia; Department of Psychology and Neuroscience, University of Colorado at Boulder, Boulder, Colorado (M.R.H., S.F.M., L.R.W.); Department of Psychology, Hebrew University of Jerusalem, Jerusalem, Israel (Y.S.); and Chemical Biology Research Branch, National Institute on Drug Abuse and National Institute on Alcohol Abuse and Alcoholism, Rockville, Maryland (K.C.R.)
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Eric L. Barker
Disciplines of Pharmacology (M.R.H., P.M.G.) and Physiology (M.R.H.), School of Medical Science, University of Adelaide, South Australia, Australia; Department of Psychology and Neuroscience, University of Colorado at Boulder, Boulder, Colorado (M.R.H., S.F.M., L.R.W.); Department of Psychology, Hebrew University of Jerusalem, Jerusalem, Israel (Y.S.); and Chemical Biology Research Branch, National Institute on Drug Abuse and National Institute on Alcohol Abuse and Alcoholism, Rockville, Maryland (K.C.R.)
Roles: ASSOCIATE EDITOR
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Article Information

vol. 63 no. 3 772-810
DOI 
https://doi.org/10.1124/pr.110.004135
PubMed 
21752874

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0031-6997
Online ISSN 
1521-0081
History 
  • Published online July 19, 2011.

Article Versions

  • Earlier version (July 13, 2011 - 05:43).
  • You are viewing the most recent version of this article.
Copyright & Usage 
U.S. Government work not protected by U.S. copyright

Author Information

  1. Mark R. Hutchinson,
  2. Yehuda Shavit,
  3. Peter M. Grace,
  4. Kenner C. Rice,
  5. Steven F. Maier, and
  6. Linda R. Watkins
  1. Disciplines of Pharmacology (M.R.H., P.M.G.) and Physiology (M.R.H.), School of Medical Science, University of Adelaide, South Australia, Australia; Department of Psychology and Neuroscience, University of Colorado at Boulder, Boulder, Colorado (M.R.H., S.F.M., L.R.W.); Department of Psychology, Hebrew University of Jerusalem, Jerusalem, Israel (Y.S.); and Chemical Biology Research Branch, National Institute on Drug Abuse and National Institute on Alcohol Abuse and Alcoholism, Rockville, Maryland (K.C.R.)
  1. Eric L. Barker, ASSOCIATE EDITOR
  1. Address correspondence to:
    Dr Mark R. Hutchinson, Discipline of Physiology, School of Medical Science, University of Adelaide, South Australia, Australia, 5005. E-mail: mark.hutchinson{at}adelaide.edu.au
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Funding

  • National Institutes of Health

    K05-DA024044

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Pharmacological Reviews: 63 (3)
Pharmacological Reviews
Vol. 63, Issue 3
1 Sep 2011
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Review ArticleReview Article

Exploring the Neuroimmunopharmacology of Opioids: An Integrative Review of Mechanisms of Central Immune Signaling and Their Implications for Opioid Analgesia

Mark R. Hutchinson, Yehuda Shavit, Peter M. Grace, Kenner C. Rice, Steven F. Maier and Linda R. Watkins
Pharmacological Reviews September 1, 2011, 63 (3) 772-810; DOI: https://doi.org/10.1124/pr.110.004135

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Review ArticleReview Article

Exploring the Neuroimmunopharmacology of Opioids: An Integrative Review of Mechanisms of Central Immune Signaling and Their Implications for Opioid Analgesia

Mark R. Hutchinson, Yehuda Shavit, Peter M. Grace, Kenner C. Rice, Steven F. Maier and Linda R. Watkins
Pharmacological Reviews September 1, 2011, 63 (3) 772-810; DOI: https://doi.org/10.1124/pr.110.004135
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  • Article
    • Abstract
    • I. Introduction
    • II. Central Immune Signaling
    • III. Opioid Analgesics and Central Immune Signaling
    • IV. Unifying the Neuronal and Central Immune Signaling Opioid Hypotheses
    • V. Conclusions
    • Acknowledgments
    • Authorship Contributions
    • Footnotes
    • References
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