Review ArticleReview Article
Functional Selectivity at the μ-Opioid Receptor: Implications for Understanding Opioid Analgesia and Tolerance
Kirsten M. Raehal, Cullen L. Schmid, Chad E. Groer and Laura M. Bohn
David R. Sibley, ASSOCIATE EDITOR
Pharmacological Reviews December 2011, 63 (4) 1001-1019; DOI: https://doi.org/10.1124/pr.111.004598
Kirsten M. Raehal
Molecular Therapeutics and Neuroscience, The Scripps Research Institute, Jupiter, Florida
Cullen L. Schmid
Molecular Therapeutics and Neuroscience, The Scripps Research Institute, Jupiter, Florida
Chad E. Groer
Molecular Therapeutics and Neuroscience, The Scripps Research Institute, Jupiter, Florida
Laura M. Bohn
Molecular Therapeutics and Neuroscience, The Scripps Research Institute, Jupiter, Florida
David R. Sibley
Molecular Therapeutics and Neuroscience, The Scripps Research Institute, Jupiter, Florida
Roles: ASSOCIATE EDITOR
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In this issue
Review ArticleReview Article
FUNCTIONAL SELECTIVITY AT THE μOR
Kirsten M. Raehal, Cullen L. Schmid, Chad E. Groer and Laura M. Bohn
Pharmacological Reviews December 1, 2011, 63 (4) 1001-1019; DOI: https://doi.org/10.1124/pr.111.004598
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- Article
- Abstract
- I. Introduction
- II. Biased Agonism with Respect to G Protein Coupling
- III. Biased Agonism with Respect to Activation of Second Messengers
- IV. Biased Agonism with Respect to μOR Phosphorylation
- V. Biased Agonism with Respect to Recruitment of β-Arrestin2
- VI. Biased Agonism with Respect to Receptor Desensitization
- VII. Biased Agonism with Respect to Receptor Internalization
- VIII. Biased Agonism with Respect to β-Arrestin-Mediated Signaling
- IX. Biased Agonism and Antinociceptive Tolerance
- X. Conclusions
- Acknowledgments
- Authorship Contributions
- Footnotes
- References
- Figures & Data
- Info & Metrics
- eLetters
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