Review ArticleReview Article
The Significance of G Protein-Coupled Receptor Crystallography for Drug Discovery
John A. Salon, David T. Lodowski and Krzysztof Palczewski
Dianne M. Perez, ASSOCIATE EDITOR
Pharmacological Reviews December 2011, 63 (4) 901-937; DOI: https://doi.org/10.1124/pr.110.003350
John A. Salon
Department of Molecular Structure, Amgen Incorporated, Thousand Oaks, California (J.A.S.); and Department of Pharmacology, School of Medicine, Case Western Reserve University, Cleveland, Ohio (D.T.L., K.P.)
David T. Lodowski
Department of Molecular Structure, Amgen Incorporated, Thousand Oaks, California (J.A.S.); and Department of Pharmacology, School of Medicine, Case Western Reserve University, Cleveland, Ohio (D.T.L., K.P.)
Krzysztof Palczewski
Department of Molecular Structure, Amgen Incorporated, Thousand Oaks, California (J.A.S.); and Department of Pharmacology, School of Medicine, Case Western Reserve University, Cleveland, Ohio (D.T.L., K.P.)
Dianne M. Perez
Department of Molecular Structure, Amgen Incorporated, Thousand Oaks, California (J.A.S.); and Department of Pharmacology, School of Medicine, Case Western Reserve University, Cleveland, Ohio (D.T.L., K.P.)
Roles: ASSOCIATE EDITOR

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In this issue
Review ArticleReview Article
GPCRs AND DRUG DISCOVERY
John A. Salon, David T. Lodowski and Krzysztof Palczewski
Pharmacological Reviews December 1, 2011, 63 (4) 901-937; DOI: https://doi.org/10.1124/pr.110.003350
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- Article
- Abstract
- I. Introduction
- II. Current Challenges and Opportunities in G Protein-Coupled Receptor Drug Discovery
- III. History of G Protein-Coupled Receptor Structural Clarification
- IV. Advances in G Protein-Coupled Receptor Structural Determination
- V. Ramifications for G Protein-Coupled Receptor Drug Discovery
- VI. Unresolved Issues and Concluding Remarks
- Acknowledgments
- Authorship Contributions
- Note Added in Proof
- Footnotes
- References
- Figures & Data
- Info & Metrics
- eLetters
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