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Review ArticleReview Article

Pharmacological Actions of Statins: A Critical Appraisal in the Management of Cancer

Patrizia Gazzerro, Maria Chiara Proto, Giuseppina Gangemi, Anna Maria Malfitano, Elena Ciaglia, Simona Pisanti, Antonietta Santoro, Chiara Laezza and Maurizio Bifulco
Michael M. Gottesman, ASSOCIATE EDITOR
Pharmacological Reviews January 2012, 64 (1) 102-146; DOI: https://doi.org/10.1124/pr.111.004994
Patrizia Gazzerro
Department of Pharmaceutical and Biomedical Sciences, University of Salerno, Fisciano, Italy (P.G., M.C.P., G.G., A.M.M., E.C., S.P., A.S., M.B.); and Istituto di Endocrinologia e Oncologia Sperimentale, Consiglio Nazionale delle Ricerche, Napoli, Italy (C.L.)
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Maria Chiara Proto
Department of Pharmaceutical and Biomedical Sciences, University of Salerno, Fisciano, Italy (P.G., M.C.P., G.G., A.M.M., E.C., S.P., A.S., M.B.); and Istituto di Endocrinologia e Oncologia Sperimentale, Consiglio Nazionale delle Ricerche, Napoli, Italy (C.L.)
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Giuseppina Gangemi
Department of Pharmaceutical and Biomedical Sciences, University of Salerno, Fisciano, Italy (P.G., M.C.P., G.G., A.M.M., E.C., S.P., A.S., M.B.); and Istituto di Endocrinologia e Oncologia Sperimentale, Consiglio Nazionale delle Ricerche, Napoli, Italy (C.L.)
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Anna Maria Malfitano
Department of Pharmaceutical and Biomedical Sciences, University of Salerno, Fisciano, Italy (P.G., M.C.P., G.G., A.M.M., E.C., S.P., A.S., M.B.); and Istituto di Endocrinologia e Oncologia Sperimentale, Consiglio Nazionale delle Ricerche, Napoli, Italy (C.L.)
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Elena Ciaglia
Department of Pharmaceutical and Biomedical Sciences, University of Salerno, Fisciano, Italy (P.G., M.C.P., G.G., A.M.M., E.C., S.P., A.S., M.B.); and Istituto di Endocrinologia e Oncologia Sperimentale, Consiglio Nazionale delle Ricerche, Napoli, Italy (C.L.)
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Simona Pisanti
Department of Pharmaceutical and Biomedical Sciences, University of Salerno, Fisciano, Italy (P.G., M.C.P., G.G., A.M.M., E.C., S.P., A.S., M.B.); and Istituto di Endocrinologia e Oncologia Sperimentale, Consiglio Nazionale delle Ricerche, Napoli, Italy (C.L.)
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Antonietta Santoro
Department of Pharmaceutical and Biomedical Sciences, University of Salerno, Fisciano, Italy (P.G., M.C.P., G.G., A.M.M., E.C., S.P., A.S., M.B.); and Istituto di Endocrinologia e Oncologia Sperimentale, Consiglio Nazionale delle Ricerche, Napoli, Italy (C.L.)
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Chiara Laezza
Department of Pharmaceutical and Biomedical Sciences, University of Salerno, Fisciano, Italy (P.G., M.C.P., G.G., A.M.M., E.C., S.P., A.S., M.B.); and Istituto di Endocrinologia e Oncologia Sperimentale, Consiglio Nazionale delle Ricerche, Napoli, Italy (C.L.)
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Maurizio Bifulco
Department of Pharmaceutical and Biomedical Sciences, University of Salerno, Fisciano, Italy (P.G., M.C.P., G.G., A.M.M., E.C., S.P., A.S., M.B.); and Istituto di Endocrinologia e Oncologia Sperimentale, Consiglio Nazionale delle Ricerche, Napoli, Italy (C.L.)
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Michael M. Gottesman
Department of Pharmaceutical and Biomedical Sciences, University of Salerno, Fisciano, Italy (P.G., M.C.P., G.G., A.M.M., E.C., S.P., A.S., M.B.); and Istituto di Endocrinologia e Oncologia Sperimentale, Consiglio Nazionale delle Ricerche, Napoli, Italy (C.L.)
Roles: ASSOCIATE EDITOR
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Pharmacological Reviews: 64 (1)
Pharmacological Reviews
Vol. 64, Issue 1
1 Jan 2012
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Review ArticleReview Article

STATINS AND CANCER: PROS AND CONS

Patrizia Gazzerro, Maria Chiara Proto, Giuseppina Gangemi, Anna Maria Malfitano, Elena Ciaglia, Simona Pisanti, Antonietta Santoro, Chiara Laezza and Maurizio Bifulco
Pharmacological Reviews January 1, 2012, 64 (1) 102-146; DOI: https://doi.org/10.1124/pr.111.004994

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Review ArticleReview Article

STATINS AND CANCER: PROS AND CONS

Patrizia Gazzerro, Maria Chiara Proto, Giuseppina Gangemi, Anna Maria Malfitano, Elena Ciaglia, Simona Pisanti, Antonietta Santoro, Chiara Laezza and Maurizio Bifulco
Pharmacological Reviews January 1, 2012, 64 (1) 102-146; DOI: https://doi.org/10.1124/pr.111.004994
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  • Article
    • Abstract
    • I. Introduction
    • II. The Isoprenylated Proteins
    • III. The Pharmacology of Statins
    • IV. Effects of the Statins on Tissues and Biological Processes
    • V. Statins and Cancer
    • VI. Conclusions and Future Directions
    • Acknowledgments
    • Authorship Contributions
    • Footnotes
    • References
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