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Review ArticleReview Article

Serotonin and Blood Pressure Regulation

Stephanie W. Watts, Shaun F. Morrison, Robert Patrick Davis and Susan M. Barman
Lynette C. Daws, ASSOCIATE EDITOR
Pharmacological Reviews April 2012, 64 (2) 359-388; DOI: https://doi.org/10.1124/pr.111.004697
Stephanie W. Watts
Department of Pharmacology and Toxicology, Michigan State University, East Lansing, Michigan (S.W.W., R.P.D., S.M.B.); and Department of Neurological Surgery, Oregon Health and Science University, Portland, Oregon (S.F.M.)
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Shaun F. Morrison
Department of Pharmacology and Toxicology, Michigan State University, East Lansing, Michigan (S.W.W., R.P.D., S.M.B.); and Department of Neurological Surgery, Oregon Health and Science University, Portland, Oregon (S.F.M.)
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Robert Patrick Davis
Department of Pharmacology and Toxicology, Michigan State University, East Lansing, Michigan (S.W.W., R.P.D., S.M.B.); and Department of Neurological Surgery, Oregon Health and Science University, Portland, Oregon (S.F.M.)
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Susan M. Barman
Department of Pharmacology and Toxicology, Michigan State University, East Lansing, Michigan (S.W.W., R.P.D., S.M.B.); and Department of Neurological Surgery, Oregon Health and Science University, Portland, Oregon (S.F.M.)
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Lynette C. Daws
Department of Pharmacology and Toxicology, Michigan State University, East Lansing, Michigan (S.W.W., R.P.D., S.M.B.); and Department of Neurological Surgery, Oregon Health and Science University, Portland, Oregon (S.F.M.)
Roles: ASSOCIATE EDITOR
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Abstract

5-Hydroxytryptamine (5-HT; serotonin) was discovered more than 60 years ago as a substance isolated from blood. The neural effects of 5-HT have been well investigated and understood, thanks in part to the pharmacological tools available to dissect the serotonergic system and the development of the frequently prescribed selective serotonin-reuptake inhibitors. By contrast, our understanding of the role of 5-HT in the control and modification of blood pressure pales in comparison. Here we focus on the role of 5-HT in systemic blood pressure control. This review provides an in-depth study of the function and pharmacology of 5-HT in those tissues that can modify blood pressure (blood, vasculature, heart, adrenal gland, kidney, brain), with a focus on the autonomic nervous system that includes mechanisms of action and pharmacology of 5-HT within each system. We compare the change in blood pressure produced in different species by short- and long-term administration of 5-HT or selective serotonin receptor agonists. To further our understanding of the mechanisms through which 5-HT modifies blood pressure, we also describe the blood pressure effects of commonly used drugs that modify the actions of 5-HT. The pharmacology and physiological actions of 5-HT in modifying blood pressure are important, given its involvement in circulatory shock, orthostatic hypotension, serotonin syndrome and hypertension.

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  • This article is available online at http://pharmrev.aspetjournals.org.

    http://dx.doi.org/10.1124/pr.111.004697.

  • © 2012 by The American Society for Pharmacology and Experimental Therapeutics
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Pharmacological Reviews: 64 (2)
Pharmacological Reviews
Vol. 64, Issue 2
1 Apr 2012
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Review ArticleReview Article

5-HT AND BLOOD PRESSURE

Stephanie W. Watts, Shaun F. Morrison, Robert Patrick Davis and Susan M. Barman
Pharmacological Reviews April 1, 2012, 64 (2) 359-388; DOI: https://doi.org/10.1124/pr.111.004697

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Review ArticleReview Article

5-HT AND BLOOD PRESSURE

Stephanie W. Watts, Shaun F. Morrison, Robert Patrick Davis and Susan M. Barman
Pharmacological Reviews April 1, 2012, 64 (2) 359-388; DOI: https://doi.org/10.1124/pr.111.004697
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  • Article
    • Abstract
    • I. Introduction
    • II. 5-Hydroxytryptamine Biochemistry and Models
    • III. 5-Hydroxytryptamine Receptor Pharmacology
    • IV. Intersections of 5-Hydroxytryptamine and the Cardiovascular System that Affect Blood Pressure
    • V. Effect of 5-Hydroxytryptamine on Blood Pressure: Whole-Animal Studies
    • VI. 5-Hydroxytryptamine, Pharmaceutical Compounds and Clinical Situations
    • VII. Conclusions and Outstanding Questions
    • Acknowledgments
    • Authorship Contributions
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