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Review ArticleReview Article

Molecular Mechanisms Regulating the Vascular Prostacyclin Pathways and Their Adaptation during Pregnancy and in the Newborn

Batoule H. Majed and Raouf A. Khalil
Christopher J. Garland, ASSOCIATE EDITOR
Pharmacological Reviews July 2012, 64 (3) 540-582; DOI: https://doi.org/10.1124/pr.111.004770
Batoule H. Majed
Vascular Surgery Research Laboratory, Division of Vascular and Endovascular Surgery, Brigham and Women's Hospital, and Harvard Medical School, Boston, Massachusetts
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Raouf A. Khalil
Vascular Surgery Research Laboratory, Division of Vascular and Endovascular Surgery, Brigham and Women's Hospital, and Harvard Medical School, Boston, Massachusetts
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Christopher J. Garland
Vascular Surgery Research Laboratory, Division of Vascular and Endovascular Surgery, Brigham and Women's Hospital, and Harvard Medical School, Boston, Massachusetts
Roles: ASSOCIATE EDITOR
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Article Information

vol. 64 no. 3 540-582
DOI 
https://doi.org/10.1124/pr.111.004770
PubMed 
22679221

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0031-6997
Online ISSN 
1521-0081
History 
  • Published online July 2, 2012.

Article Versions

  • Earlier version (June 7, 2012 - 12:04).
  • You are viewing the most recent version of this article.
Copyright & Usage 
© 2012 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Batoule H. Majed and
  2. Raouf A. Khalil
  1. Vascular Surgery Research Laboratory, Division of Vascular and Endovascular Surgery, Brigham and Women's Hospital, and Harvard Medical School, Boston, Massachusetts
  1. Christopher J. Garland, ASSOCIATE EDITOR
  1. Address correspondence to:
    Dr. Raouf A Khalil, Harvard Medical School, Brigham and Women's Hospital, Division of Vascular Surgery, 75 Francis St., Boston, MA 02115. E-mail: raouf_khalil{at}hms.harvard.edu
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Funding

  • National Institutes of Health

    HL65998; HL98724; HD60702

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Pharmacological Reviews: 64 (3)
Pharmacological Reviews
Vol. 64, Issue 3
1 Jul 2012
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Review ArticleReview Article

VASCULAR PROSTACYCLIN IN PREGNANCY AND NEONATES

Batoule H. Majed and Raouf A. Khalil
Pharmacological Reviews July 1, 2012, 64 (3) 540-582; DOI: https://doi.org/10.1124/pr.111.004770

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Review ArticleReview Article

VASCULAR PROSTACYCLIN IN PREGNANCY AND NEONATES

Batoule H. Majed and Raouf A. Khalil
Pharmacological Reviews July 1, 2012, 64 (3) 540-582; DOI: https://doi.org/10.1124/pr.111.004770
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  • Article
    • Abstract
    • I. Introduction
    • II. Arachidonic Acid Metabolism and Prostacyclin Synthesis
    • IV. Prostacyclin Receptor
    • V. Effects of Prostacyclin on Blood Vessels
    • V. Alterations in the Prostacyclin Pathways in the Pathophysiology of Vascular Disease
    • VI. Prostacyclin Metabolism in Pregnancy-Associated Vascular Disorders
    • VII. Prostacyclin Metabolism and Vascular Disorders in the Newborn
    • VIII. Conclusions and Future Implications
    • Acknowledgments
    • Authorship Contributions
    • Footnotes
    • References
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