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Review ArticleReview Article

G-Protein-Coupled Receptors in Adult Neurogenesis

Van A. Doze and Dianne M. Perez
David R. Sibley, ASSOCIATE EDITOR
Pharmacological Reviews July 2012, 64 (3) 645-675; DOI: https://doi.org/10.1124/pr.111.004762
Van A. Doze
Department of Pharmacology, Physiology and Therapeutics, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, North Dakota (V.A.D.); and Department of Molecular Cardiology, Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, Ohio (D.M.P.)
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Dianne M. Perez
Department of Pharmacology, Physiology and Therapeutics, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, North Dakota (V.A.D.); and Department of Molecular Cardiology, Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, Ohio (D.M.P.)
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David R. Sibley
Department of Pharmacology, Physiology and Therapeutics, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, North Dakota (V.A.D.); and Department of Molecular Cardiology, Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, Ohio (D.M.P.)
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Abstract

The importance of adult neurogenesis has only recently been accepted, resulting in a completely new field of investigation within stem cell biology. The regulation and functional significance of adult neurogenesis is currently an area of highly active research. G-protein-coupled receptors (GPCRs) have emerged as potential modulators of adult neurogenesis. GPCRs represent a class of proteins with significant clinical importance, because approximately 30% of all modern therapeutic treatments target these receptors. GPCRs bind to a large class of neurotransmitters and neuromodulators such as norepinephrine, dopamine, and serotonin. Besides their typical role in cellular communication, GPCRs are expressed on adult neural stem cells and their progenitors that relay specific signals to regulate the neurogenic process. This review summarizes the field of adult neurogenesis and its methods and specifies the roles of various GPCRs and their signal transduction pathways that are involved in the regulation of adult neural stem cells and their progenitors. Current evidence supporting adult neurogenesis as a model for self-repair in neuropathologic conditions, adult neural stem cell therapeutic strategies, and potential avenues for GPCR-based therapeutics are also discussed.

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  • This article is available online at http://pharmrev.aspetjournals.org.

    http://dx.doi.org/10.1124/pr.111.004762.

  • © 2012 by The American Society for Pharmacology and Experimental Therapeutics
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Pharmacological Reviews: 64 (3)
Pharmacological Reviews
Vol. 64, Issue 3
1 Jul 2012
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Review ArticleReview Article

GPCRS IN ADULT NEUROGENESIS

Van A. Doze and Dianne M. Perez
Pharmacological Reviews July 1, 2012, 64 (3) 645-675; DOI: https://doi.org/10.1124/pr.111.004762

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Review ArticleReview Article

GPCRS IN ADULT NEUROGENESIS

Van A. Doze and Dianne M. Perez
Pharmacological Reviews July 1, 2012, 64 (3) 645-675; DOI: https://doi.org/10.1124/pr.111.004762
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  • Article
    • Abstract
    • I. Introduction
    • II. General Features of Neural Stem Cells and Progenitors
    • III. Adult versus Embryonic Neurogenesis
    • IV. Methods for Analyzing Adult Neurogenesis
    • V. Regulation of Adult Neurogenesis in the Brain Vascular Niche and Choroid Plexus
    • VI. G-Protein-Coupled Receptor Regulation of Adult Neurogenesis
    • VII. Implications of Adult Neurogenesis in Pathological Conditions
    • VIII. Adult Neural Stem Cell Therapy in the Central Nervous System
    • IX. Therapeutic Potential of G-Protein-Coupled Receptor-Based Neural Stem Cell Strategies
    • X. Concluding Remarks and Future Directions
    • Acknowledgments
    • Authorship Contributions
    • Footnotes
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