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Review ArticleReview Article

Thinking Outside the Cleft to Understand Synaptic Activity: Contribution of the Cystine-Glutamate Antiporter (System xc−) to Normal and Pathological Glutamatergic Signaling

Richard Bridges, Victoria Lutgen, Doug Lobner and David A. Baker
Lynette C. Daws, ASSOCIATE EDITOR
Pharmacological Reviews July 2012, 64 (3) 780-802; DOI: https://doi.org/10.1124/pr.110.003889
Richard Bridges
Center for Structural and Functional Neuroscience, Department of Biomedical and Pharmaceutical Sciences, University of Montana, Missoula, Montana (R.B.); and Department of Biomedical Sciences, Marquette University, Milwaukee, Wisconsin (V.L., D.L., D.A.B.)
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Victoria Lutgen
Center for Structural and Functional Neuroscience, Department of Biomedical and Pharmaceutical Sciences, University of Montana, Missoula, Montana (R.B.); and Department of Biomedical Sciences, Marquette University, Milwaukee, Wisconsin (V.L., D.L., D.A.B.)
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Doug Lobner
Center for Structural and Functional Neuroscience, Department of Biomedical and Pharmaceutical Sciences, University of Montana, Missoula, Montana (R.B.); and Department of Biomedical Sciences, Marquette University, Milwaukee, Wisconsin (V.L., D.L., D.A.B.)
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David A. Baker
Center for Structural and Functional Neuroscience, Department of Biomedical and Pharmaceutical Sciences, University of Montana, Missoula, Montana (R.B.); and Department of Biomedical Sciences, Marquette University, Milwaukee, Wisconsin (V.L., D.L., D.A.B.)
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Lynette C. Daws
Center for Structural and Functional Neuroscience, Department of Biomedical and Pharmaceutical Sciences, University of Montana, Missoula, Montana (R.B.); and Department of Biomedical Sciences, Marquette University, Milwaukee, Wisconsin (V.L., D.L., D.A.B.)
Roles: ASSOCIATE EDITOR
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Article Information

vol. 64 no. 3 780-802
DOI 
https://doi.org/10.1124/pr.110.003889
PubMed 
22759795

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0031-6997
Online ISSN 
1521-0081
History 
  • Published online July 2, 2012.

Copyright & Usage 
© 2012 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Richard Bridges,
  2. Victoria Lutgen,
  3. Doug Lobner, and
  4. David A. Baker
  1. Center for Structural and Functional Neuroscience, Department of Biomedical and Pharmaceutical Sciences, University of Montana, Missoula, Montana (R.B.); and Department of Biomedical Sciences, Marquette University, Milwaukee, Wisconsin (V.L., D.L., D.A.B.)
  1. Lynette C. Daws, ASSOCIATE EDITOR
  1. Address correspondence to:
    David Baker Department of Biomedical Sciences, PO Box 1881, SCH 446, Marquette University, Milwaukee, WI 53201-1881. E-mail: david.baker{at}mu.edu
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Funding

  • National Institutes of Health

    DA025617; MH083417

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Pharmacological Reviews: 64 (3)
Pharmacological Reviews
Vol. 64, Issue 3
1 Jul 2012
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Review ArticleReview Article

SYSTEM Xc− AND DISEASE

Richard Bridges, Victoria Lutgen, Doug Lobner and David A. Baker
Pharmacological Reviews July 1, 2012, 64 (3) 780-802; DOI: https://doi.org/10.1124/pr.110.003889

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Review ArticleReview Article

SYSTEM Xc− AND DISEASE

Richard Bridges, Victoria Lutgen, Doug Lobner and David A. Baker
Pharmacological Reviews July 1, 2012, 64 (3) 780-802; DOI: https://doi.org/10.1124/pr.110.003889
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  • Article
    • Abstract
    • I. Introduction
    • II. Glutamate Homeostasis
    • III. Cystine Transport
    • IV. System xc− and Glutathione Synthesis in the Central Nervous System
    • V. Role of System xc− in Disease
    • VI. Summary
    • Acknowledgments
    • Authorship Contributions
    • Footnotes
    • References
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