Table of Contents

Review Articles

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  Purinergic Signaling in the Airways

  Geoffrey Burnstock, Inge Brouns, Dirk Adriaensen and Jean-Pierre Timmermans

  Dianne M. Perez, ASSOCIATE EDITOR

  Pharmacological Reviews October 2012, 64 (4) 834-868; DOI: https://doi.org/10.1124/pr.111.005389
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  Insights into the Neurobiology of the Nicotinic Cholinergic System and Nicotine Addiction from Mice Expressing Nicotinic Receptors Harboring Gain-of-Function Mutations

  Ryan M. Drenan and Henry A. Lester

  Burt M. Sharp, ASSOCIATE EDITOR

  Pharmacological Reviews October 2012, 64 (4) 869-879; DOI: https://doi.org/10.1124/pr.111.004671
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  Diabetic Peripheral Neuropathy: Should a Chaperone Accompany Our Therapeutic Approach?

  Kevin L. Farmer, Chengyuan Li and Rick T. Dobrowsky

  Emily E. Scott, ASSOCIATE EDITOR

  Pharmacological Reviews October 2012, 64 (4) 880-900; DOI: https://doi.org/10.1124/pr.111.005314
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  Unraveling the Time Domains of Corticosteroid Hormone Influences on Brain Activity: Rapid, Slow, and Chronic Modes

  Marian Joëls, R. Angela Sarabdjitsingh and Henk Karst

  Glenda E. Gillies, ASSOCIATE EDITOR

  Pharmacological Reviews October 2012, 64 (4) 901-938; DOI: https://doi.org/10.1124/pr.112.005892
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  Unravelling the Mystery of Capsaicin: A Tool to Understand and Treat Pain

  Jessica O'Neill, Christina Brock, Anne Estrup Olesen, Trine Andresen, Matias Nilsson and Anthony H. Dickenson

  Annette C. Dolphin, ASSOCIATE EDITOR

  Pharmacological Reviews October 2012, 64 (4) 939-971; DOI: https://doi.org/10.1124/pr.112.006163
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  Synthetic Oleanane Triterpenoids: Multifunctional Drugs with a Broad Range of Applications for Prevention and Treatment of Chronic Disease

  Karen T. Liby and Michael B. Sporn

  Timothy A. Esbenshade, ASSOCIATE EDITOR

  Pharmacological Reviews October 2012, 64 (4) 972-1003; DOI: https://doi.org/10.1124/pr.111.004846
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  Tumor Necrosis Factor-Induced Cerebral Insulin Resistance in Alzheimer's Disease Links Numerous Treatment Rationales

  Ian Clark, Craig Atwood, Richard Bowen, Gilberto Paz-Filho and Bryce Vissel

  David R. Sibley, ASSOCIATE EDITOR

  Pharmacological Reviews October 2012, 64 (4) 1004-1026; DOI: https://doi.org/10.1124/pr.112.005850
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  Inhibition of PI3K Signaling Spurs New Therapeutic Opportunities in Inflammatory/Autoimmune Diseases and Hematological Malignancies

  John G. Foster, Matthew D. Blunt, Edward Carter and Stephen G. Ward

  David R. Sibley, ASSOCIATE EDITOR

  Pharmacological Reviews October 2012, 64 (4) 1027-1054; DOI: https://doi.org/10.1124/pr.110.004051
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  Molecular Basis of Electrophilic and Oxidative Defense: Promises and Perils of Nrf2

  Qiang Ma and Xiaoqing He

  David R. Sibley, ASSOCIATE EDITOR

  Pharmacological Reviews October 2012, 64 (4) 1055-1081; DOI: https://doi.org/10.1124/pr.110.004333