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Review ArticleReview Article

Tumor Necrosis Factor-Induced Cerebral Insulin Resistance in Alzheimer's Disease Links Numerous Treatment Rationales

Ian Clark, Craig Atwood, Richard Bowen, Gilberto Paz-Filho and Bryce Vissel
David R. Sibley, ASSOCIATE EDITOR
Pharmacological Reviews October 2012, 64 (4) 1004-1026; DOI: https://doi.org/10.1124/pr.112.005850
Ian Clark
Research School of Biology, Australian National University, Canberra, Australia (I.C.); Department of Medicine, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin (C.A.); School of Exercise, Biomedical and Health Sciences, Edith Cowan University, Joondalup, Australia (C.A.); OTB Research, Charleston, South Carolina (R.B.); John Curtin School of Medical Research, Australian National University, Canberra, Australia (G.P.-F.); and the Neurodegeneration Research Group, Garvan Institute of Medical Research, Sydney, Australia (B.V.)
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Craig Atwood
Research School of Biology, Australian National University, Canberra, Australia (I.C.); Department of Medicine, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin (C.A.); School of Exercise, Biomedical and Health Sciences, Edith Cowan University, Joondalup, Australia (C.A.); OTB Research, Charleston, South Carolina (R.B.); John Curtin School of Medical Research, Australian National University, Canberra, Australia (G.P.-F.); and the Neurodegeneration Research Group, Garvan Institute of Medical Research, Sydney, Australia (B.V.)
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Richard Bowen
Research School of Biology, Australian National University, Canberra, Australia (I.C.); Department of Medicine, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin (C.A.); School of Exercise, Biomedical and Health Sciences, Edith Cowan University, Joondalup, Australia (C.A.); OTB Research, Charleston, South Carolina (R.B.); John Curtin School of Medical Research, Australian National University, Canberra, Australia (G.P.-F.); and the Neurodegeneration Research Group, Garvan Institute of Medical Research, Sydney, Australia (B.V.)
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Gilberto Paz-Filho
Research School of Biology, Australian National University, Canberra, Australia (I.C.); Department of Medicine, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin (C.A.); School of Exercise, Biomedical and Health Sciences, Edith Cowan University, Joondalup, Australia (C.A.); OTB Research, Charleston, South Carolina (R.B.); John Curtin School of Medical Research, Australian National University, Canberra, Australia (G.P.-F.); and the Neurodegeneration Research Group, Garvan Institute of Medical Research, Sydney, Australia (B.V.)
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Bryce Vissel
Research School of Biology, Australian National University, Canberra, Australia (I.C.); Department of Medicine, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin (C.A.); School of Exercise, Biomedical and Health Sciences, Edith Cowan University, Joondalup, Australia (C.A.); OTB Research, Charleston, South Carolina (R.B.); John Curtin School of Medical Research, Australian National University, Canberra, Australia (G.P.-F.); and the Neurodegeneration Research Group, Garvan Institute of Medical Research, Sydney, Australia (B.V.)
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David R. Sibley
Research School of Biology, Australian National University, Canberra, Australia (I.C.); Department of Medicine, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin (C.A.); School of Exercise, Biomedical and Health Sciences, Edith Cowan University, Joondalup, Australia (C.A.); OTB Research, Charleston, South Carolina (R.B.); John Curtin School of Medical Research, Australian National University, Canberra, Australia (G.P.-F.); and the Neurodegeneration Research Group, Garvan Institute of Medical Research, Sydney, Australia (B.V.)
Roles: ASSOCIATE EDITOR
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Pharmacological Reviews: 64 (4)
Pharmacological Reviews
Vol. 64, Issue 4
1 Oct 2012
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Review ArticleReview Article

TNF CAUSES INSULIN RESISTANCE: IMPLICATIONS FOR AD

Ian Clark, Craig Atwood, Richard Bowen, Gilberto Paz-Filho and Bryce Vissel
Pharmacological Reviews October 1, 2012, 64 (4) 1004-1026; DOI: https://doi.org/10.1124/pr.112.005850

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Review ArticleReview Article

TNF CAUSES INSULIN RESISTANCE: IMPLICATIONS FOR AD

Ian Clark, Craig Atwood, Richard Bowen, Gilberto Paz-Filho and Bryce Vissel
Pharmacological Reviews October 1, 2012, 64 (4) 1004-1026; DOI: https://doi.org/10.1124/pr.112.005850
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  • Article
    • Abstract
    • I. Introduction
    • II. Gonadotropins, Sex Steroids, Tumor Necrosis Factor, and Alzheimer's Disease
    • III. Tumor Necrosis Factor and Alzheimer's Disease
    • IV. Tumor Necrosis Factor, Amyloid β, and τ
    • V. Insulin
    • VI. Tumor Necrosis Factor and Glycogen Synthase Kinase-3
    • VII. Tumor Necrosis Factor and Mitochondrial Dysfunction
    • VIII. Tumor Necrosis Factor and Progenitor Cells
    • IX. Streptozotocin
    • X. The Broader Picture—Stroke, Traumatic Brain Injury, and Infectious Disease
    • XI. Therapeutic Implications
    • XII. Conclusions
    • Authorship Contributions
    • Footnotes
    • References
  • Figures & Data
  • Info & Metrics
  • eLetters
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