Review ArticleReview Article
Molecular Basis of Electrophilic and Oxidative Defense: Promises and Perils of Nrf2
Qiang Ma and Xiaoqing He
David R. Sibley, ASSOCIATE EDITOR
Pharmacological Reviews October 2012, 64 (4) 1055-1081; DOI: https://doi.org/10.1124/pr.110.004333
Qiang Ma
Receptor Biology Laboratory, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia
Xiaoqing He
Receptor Biology Laboratory, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia
David R. Sibley
Receptor Biology Laboratory, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia
Roles: ASSOCIATE EDITOR

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In this issue
Review ArticleReview Article
NRF2 FUNCTION AND SIGNALING
Qiang Ma and Xiaoqing He
Pharmacological Reviews October 1, 2012, 64 (4) 1055-1081; DOI: https://doi.org/10.1124/pr.110.004333
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- Article
- Abstract
- I. Introduction
- II. The Nuclear Factor Erythroid 2-Related Factor 2–Antioxidant Response Element (Nrf2-ARE) Pathway: Finding the Xenobiotic-Activated Receptor
- III. Mechanism of Nuclear Factor Erythroid 2-Related Factor 2 Regulation: Insights from Structure
- IV. Nuclear Factor Erythroid 2-Related Factor 2 Signaling in Disease and Toxicity: Expecting the Unexpected
- V. Genetics and Cancer Mutation: Revealing the Perilous Side of Nuclear Factor Erythroid 2-Related Factor 2 Signaling Activation
- VI. Targeting the Nuclear Factor Erythroid 2-Related Factor 2 Signaling-Antioxidant Response Element Pathway for Drug Development: Going beyond the Promise
- VII. Conclusion
- Authorship Contributions
- Footnotes
- References
- Figures & Data
- Info & Metrics
- eLetters
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