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Review ArticleReview Article

Unravelling the Mystery of Capsaicin: A Tool to Understand and Treat Pain

Jessica O'Neill, Christina Brock, Anne Estrup Olesen, Trine Andresen, Matias Nilsson and Anthony H. Dickenson
Annette C. Dolphin, ASSOCIATE EDITOR
Pharmacological Reviews October 2012, 64 (4) 939-971; DOI: https://doi.org/10.1124/pr.112.006163
Jessica O'Neill
Neuroscience, Physiology and Pharmacology, University College London (J.O., A.H.D.); and Mech-Sense, Department of Gastroenterology, Aalborg Hospital, Aarhus University, Denmark (C.B., A.E.O., T.A., M.N.)
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Christina Brock
Neuroscience, Physiology and Pharmacology, University College London (J.O., A.H.D.); and Mech-Sense, Department of Gastroenterology, Aalborg Hospital, Aarhus University, Denmark (C.B., A.E.O., T.A., M.N.)
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Anne Estrup Olesen
Neuroscience, Physiology and Pharmacology, University College London (J.O., A.H.D.); and Mech-Sense, Department of Gastroenterology, Aalborg Hospital, Aarhus University, Denmark (C.B., A.E.O., T.A., M.N.)
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Trine Andresen
Neuroscience, Physiology and Pharmacology, University College London (J.O., A.H.D.); and Mech-Sense, Department of Gastroenterology, Aalborg Hospital, Aarhus University, Denmark (C.B., A.E.O., T.A., M.N.)
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Matias Nilsson
Neuroscience, Physiology and Pharmacology, University College London (J.O., A.H.D.); and Mech-Sense, Department of Gastroenterology, Aalborg Hospital, Aarhus University, Denmark (C.B., A.E.O., T.A., M.N.)
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Anthony H. Dickenson
Neuroscience, Physiology and Pharmacology, University College London (J.O., A.H.D.); and Mech-Sense, Department of Gastroenterology, Aalborg Hospital, Aarhus University, Denmark (C.B., A.E.O., T.A., M.N.)
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Annette C. Dolphin
Neuroscience, Physiology and Pharmacology, University College London (J.O., A.H.D.); and Mech-Sense, Department of Gastroenterology, Aalborg Hospital, Aarhus University, Denmark (C.B., A.E.O., T.A., M.N.)
Roles: ASSOCIATE EDITOR
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Article Information

vol. 64 no. 4 939-971
DOI 
https://doi.org/10.1124/pr.112.006163
PubMed 
23023032

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0031-6997
Online ISSN 
1521-0081
History 
  • Published online September 28, 2012.

Copyright & Usage 
© 2012 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Jessica O'Neill,
  2. Christina Brock,
  3. Anne Estrup Olesen,
  4. Trine Andresen,
  5. Matias Nilsson, and
  6. Anthony H. Dickenson
  1. Neuroscience, Physiology and Pharmacology, University College London (J.O., A.H.D.); and Mech-Sense, Department of Gastroenterology, Aalborg Hospital, Aarhus University, Denmark (C.B., A.E.O., T.A., M.N.)
  1. Annette C. Dolphin, ASSOCIATE EDITOR
  1. Address correspondence to:
    Jessica O'Neill, Neuroscience, Physiology and Pharmacology, University College London, Gower Street, London WC1E 6BT. E-mail: jessica.oneill{at}ucl.ac.uk
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Pharmacological Reviews: 64 (4)
Pharmacological Reviews
Vol. 64, Issue 4
1 Oct 2012
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Review ArticleReview Article

CAPSAICIN: TO UNDERSTAND AND TREAT PAIN

Jessica O'Neill, Christina Brock, Anne Estrup Olesen, Trine Andresen, Matias Nilsson and Anthony H. Dickenson
Pharmacological Reviews October 1, 2012, 64 (4) 939-971; DOI: https://doi.org/10.1124/pr.112.006163

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Review ArticleReview Article

CAPSAICIN: TO UNDERSTAND AND TREAT PAIN

Jessica O'Neill, Christina Brock, Anne Estrup Olesen, Trine Andresen, Matias Nilsson and Anthony H. Dickenson
Pharmacological Reviews October 1, 2012, 64 (4) 939-971; DOI: https://doi.org/10.1124/pr.112.006163
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  • Article
    • Abstract
    • I. Introduction
    • II. Physical and Chemical Properties of Capsaicin
    • III. Pharmacokinetics of Capsaicin
    • IV. Capsaicin Metabolism
    • V. Capsaicin Elimination
    • VI. Capsaicin Pharmacology
    • VII. Transient Receptor Potential Channels
    • VIII. Transient Receptor Potential Vanilloid 1
    • IX. Transient Receptor Potential Vanilloid 1 Splice Variants
    • X. Transient Receptor Potential Vanilloid 1 Polymorphisms
    • XI. Transient Receptor Potential Vanilloid 1 Receptor Expression in Humans in the Airways, Skin, and Viscera
    • XII. Experimental Pain Models
    • XIII. Sensitizing or Desensitizing?
    • XIV. Capsaicin As a Therapeutic Pharmacological Agent
    • XV. Conclusion
    • Acknowledgments
    • Authorship Contributions
    • Footnotes
    • References
  • Figures & Data
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  • PDF

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