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Review ArticleReview Article

Synthetic Oleanane Triterpenoids: Multifunctional Drugs with a Broad Range of Applications for Prevention and Treatment of Chronic Disease

Karen T. Liby and Michael B. Sporn
Timothy A. Esbenshade, ASSOCIATE EDITOR
Pharmacological Reviews October 2012, 64 (4) 972-1003; DOI: https://doi.org/10.1124/pr.111.004846
Karen T. Liby
Departments of Medicine and Pharmacology, Dartmouth Medical School, Hanover, New Hampshire
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Michael B. Sporn
Departments of Medicine and Pharmacology, Dartmouth Medical School, Hanover, New Hampshire
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Timothy A. Esbenshade
Departments of Medicine and Pharmacology, Dartmouth Medical School, Hanover, New Hampshire
Roles: ASSOCIATE EDITOR
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Article Information

vol. 64 no. 4 972-1003
DOI 
https://doi.org/10.1124/pr.111.004846
PubMed 
22966038

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0031-6997
Online ISSN 
1521-0081
History 
  • Published online September 28, 2012.

Article Versions

  • Earlier version (September 10, 2012 - 11:01).
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Copyright & Usage 
© 2012 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Karen T. Liby and
  2. Michael B. Sporn
  1. Departments of Medicine and Pharmacology, Dartmouth Medical School, Hanover, New Hampshire
  1. Timothy A. Esbenshade, ASSOCIATE EDITOR
  1. Address correspondence to:
    Karen Liby, Departments of Medicine and Pharmacology, Dartmouth Medical School, Remsen 524, HB7650, Hanover, NH 03755. E-mail: karen.liby{at}dartmouth.edu
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Funding

  • National Institutes of Health

    R01-CA78814

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Pharmacological Reviews: 64 (4)
Pharmacological Reviews
Vol. 64, Issue 4
1 Oct 2012
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Review ArticleReview Article

TRITERPENOIDS FOR DISEASE PREVENTION AND TREATMENT

Karen T. Liby and Michael B. Sporn
Pharmacological Reviews October 1, 2012, 64 (4) 972-1003; DOI: https://doi.org/10.1124/pr.111.004846

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Review ArticleReview Article

TRITERPENOIDS FOR DISEASE PREVENTION AND TREATMENT

Karen T. Liby and Michael B. Sporn
Pharmacological Reviews October 1, 2012, 64 (4) 972-1003; DOI: https://doi.org/10.1124/pr.111.004846
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  • Article
    • Abstract
    • I. Introduction
    • II. Inflammation and Oxidative Stress
    • III. Naturally Occurring Pentacyclic Triterpenoids
    • IV. Biological Activities In Vitro
    • V. Preclinical Biological Activities In Vivo
    • VI. Signaling Pathways and Mechanisms of Action
    • VII. Clinical Activity
    • VIII. Summary and Future Perspectives
    • Acknowledgments
    • Authorship Contributions
    • Footnotes
    • References
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