Table of Contents

Review Articles

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  A Modern Understanding of the Traditional and Nontraditional Biological Functions of Angiotensin-Converting Enzyme

  Kenneth E. Bernstein, Frank S. Ong, Wendell-Lamar B. Blackwell, Kandarp H. Shah, Jorge F. Giani, Romer A. Gonzalez-Villalobos, Xiao Z. Shen and Sebastien Fuchs

  Rhian M. Touyz, ASSOCIATE EDITOR

  Pharmacological Reviews January 2013, 65 (1) 1-46; DOI: https://doi.org/10.1124/pr.112.006809
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  CC Chemokine Receptors and Chronic Inflammation—Therapeutic Opportunities and Pharmacological Challenges

  Gemma E. White, Asif J. Iqbal and David R. Greaves

  Christopher J. Garland, ASSOCIATE EDITOR

  Pharmacological Reviews January 2013, 65 (1) 47-89; DOI: https://doi.org/10.1124/pr.111.005074
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  Homeoprotein Signaling in Development, Health, and Disease: A Shaking of Dogmas Offers Challenges and Promises from Bench to Bed

  Julien Spatazza, Elizabeth Di Lullo, Alain Joliot, Edmond Dupont, Kenneth L. Moya and Alain Prochiantz

  Glenda E. Gillies, ASSOCIATE EDITOR

  Pharmacological Reviews January 2013, 65 (1) 90-104; DOI: https://doi.org/10.1124/pr.112.006577
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  Therapeutic Potential of Mood Stabilizers Lithium and Valproic Acid: Beyond Bipolar Disorder

  Chi-Tso Chiu, Zhifei Wang, Joshua G. Hunsberger and De-Maw Chuang

  David R. Sibley, ASSOCIATE EDITOR

  Pharmacological Reviews January 2013, 65 (1) 105-142; DOI: https://doi.org/10.1124/pr.111.005512
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  The Flinders Sensitive Line Rat Model of Depression—25 Years and Still Producing

  David H. Overstreet and Gregers Wegener

  Lynette C. Daws, ASSOCIATE EDITOR

  Pharmacological Reviews January 2013, 65 (1) 143-155; DOI: https://doi.org/10.1124/pr.111.005397
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  Integrating Optogenetic and Pharmacological Approaches to Study Neural Circuit Function: Current Applications and Future Directions

  Garret D. Stuber and Alex O. Mason

  Annette C. Dolphin, ASSOCIATE EDITOR

  Pharmacological Reviews January 2013, 65 (1) 156-170; DOI: https://doi.org/10.1124/pr.111.005611
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  The Pharmacology of l-DOPA-Induced Dyskinesia in Parkinson’s Disease

  Philippe Huot, Tom H. Johnston, James B. Koprich, Susan H. Fox and Jonathan M. Brotchie

  David R. Sibley, ASSOCIATE EDITOR

  Pharmacological Reviews January 2013, 65 (1) 171-222; DOI: https://doi.org/10.1124/pr.111.005678
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  Regulation of µ-Opioid Receptors: Desensitization, Phosphorylation, Internalization, and Tolerance

  John T. Williams, Susan L. Ingram, Graeme Henderson, Charles Chavkin, Mark von Zastrow, Stefan Schulz, Thomas Koch, Christopher J. Evans and MacDonald J. Christie

  Annette C. Dolphin, ASSOCIATE EDITOR

  Pharmacological Reviews January 2013, 65 (1) 223-254; DOI: https://doi.org/10.1124/pr.112.005942
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  Individual Differences and Social Influences on the Neurobehavioral Pharmacology of Abused Drugs

  M. T. Bardo, J. L. Neisewander and T. H. Kelly

  Michael A. Nader, ASSOCIATE EDITOR

  Pharmacological Reviews January 2013, 65 (1) 255-290; DOI: https://doi.org/10.1124/pr.111.005124
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  Targeted Drug Delivery to Treat Pain and Cerebral Hypoxia

  Patrick T. Ronaldson and Thomas P. Davis

  David R. Sibley, ASSOCIATE EDITOR

  Pharmacological Reviews January 2013, 65 (1) 291-314; DOI: https://doi.org/10.1124/pr.112.005991
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  Strategies to Address Low Drug Solubility in Discovery and Development

  Hywel D. Williams, Natalie L. Trevaskis, Susan A. Charman, Ravi M. Shanker, William N. Charman, Colin W. Pouton and Christopher J. H. Porter

  Arthur Christopoulos, ASSOCIATE EDITOR

  Pharmacological Reviews January 2013, 65 (1) 315-499; DOI: https://doi.org/10.1124/pr.112.005660