Review ArticleReview Article
Homeoprotein Signaling in Development, Health, and Disease: A Shaking of Dogmas Offers Challenges and Promises from Bench to Bed
Julien Spatazza, Elizabeth Di Lullo, Alain Joliot, Edmond Dupont, Kenneth L. Moya and Alain Prochiantz
Glenda E. Gillies, ASSOCIATE EDITOR
Pharmacological Reviews January 2013, 65 (1) 90-104; DOI: https://doi.org/10.1124/pr.112.006577
Julien Spatazza
Development and Neuropharmacology Group (J.S., E.D.L., K.L.M., A.P.), and Cell Biology of Homeoproteins Group (A.J., E.D.), College de France, Centre for Interdisciplinary Research in Biology, CNRS UMR 7241/INSERM U1050, Labex Memolife, PSL Research University, Paris, France
Elizabeth Di Lullo
Development and Neuropharmacology Group (J.S., E.D.L., K.L.M., A.P.), and Cell Biology of Homeoproteins Group (A.J., E.D.), College de France, Centre for Interdisciplinary Research in Biology, CNRS UMR 7241/INSERM U1050, Labex Memolife, PSL Research University, Paris, France
Alain Joliot
Development and Neuropharmacology Group (J.S., E.D.L., K.L.M., A.P.), and Cell Biology of Homeoproteins Group (A.J., E.D.), College de France, Centre for Interdisciplinary Research in Biology, CNRS UMR 7241/INSERM U1050, Labex Memolife, PSL Research University, Paris, France
Edmond Dupont
Development and Neuropharmacology Group (J.S., E.D.L., K.L.M., A.P.), and Cell Biology of Homeoproteins Group (A.J., E.D.), College de France, Centre for Interdisciplinary Research in Biology, CNRS UMR 7241/INSERM U1050, Labex Memolife, PSL Research University, Paris, France
Kenneth L. Moya
Development and Neuropharmacology Group (J.S., E.D.L., K.L.M., A.P.), and Cell Biology of Homeoproteins Group (A.J., E.D.), College de France, Centre for Interdisciplinary Research in Biology, CNRS UMR 7241/INSERM U1050, Labex Memolife, PSL Research University, Paris, France
Alain Prochiantz
Development and Neuropharmacology Group (J.S., E.D.L., K.L.M., A.P.), and Cell Biology of Homeoproteins Group (A.J., E.D.), College de France, Centre for Interdisciplinary Research in Biology, CNRS UMR 7241/INSERM U1050, Labex Memolife, PSL Research University, Paris, France
Glenda E. Gillies
Development and Neuropharmacology Group (J.S., E.D.L., K.L.M., A.P.), and Cell Biology of Homeoproteins Group (A.J., E.D.), College de France, Centre for Interdisciplinary Research in Biology, CNRS UMR 7241/INSERM U1050, Labex Memolife, PSL Research University, Paris, France
Roles: ASSOCIATE EDITOR
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In this issue
Review ArticleReview Article
Homeoprotein Signaling in Development, Health, and Disease
Julien Spatazza, Elizabeth Di Lullo, Alain Joliot, Edmond Dupont, Kenneth L. Moya and Alain Prochiantz
Pharmacological Reviews January 1, 2013, 65 (1) 90-104; DOI: https://doi.org/10.1124/pr.112.006577
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- Article
- Abstract
- I. Introduction: The History of Homeoprotein Transduction
- II. Penetratin, Homeodomain, and Homeoprotein Internalization
- III. Homeoprotein Secretion
- IV. Non–Cell Autonomous Homeoprotein Activity in Pattern Formation
- V. Non–Cell Autonomous Homeoprotein Activity in Axon Guidance and Cell Migration
- VI. Non–Cell Autonomous Homeoprotein Activity in the Regulation of Cortex Plasticity
- VII. Homeoprotein Signal Transduction Pathways
- VIII. Therapeutic Homeoproteins
- IX. Conclusion: The Future of Homeoprotein Transduction
- Acknowledgments
- Authorship contributions
- Footnotes
- Abbreviations
- References
- Figures & Data
- Info & Metrics
- eLetters
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