Table of Contents

Review Articles

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  The Expanding Roles of Gβγ Subunits in G Protein–Coupled Receptor Signaling and Drug Action

  Shahriar M. Khan, Rory Sleno, Sarah Gora, Peter Zylbergold, Jean-Philippe Laverdure, Jean-Claude Labbé, Gregory J. Miller and Terence E. Hébert

  Eric L. Barker, ASSOCIATE EDITOR

  Pharmacological Reviews April 2013, 65 (2) 545-577; DOI: https://doi.org/10.1124/pr.111.005603
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  Pharmacologically Active Drug Metabolites: Impact on Drug Discovery and Pharmacotherapy

  R. Scott Obach

  Timothy A. Esbenshade, ASSOCIATE EDITOR

  Pharmacological Reviews April 2013, 65 (2) 578-640; DOI: https://doi.org/10.1124/pr.111.005439
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  New Horizons in Cellular Regulation by Inositol Polyphosphates: Insights from the Pancreatic β-Cell

  Christopher J. Barker and Per-Olof Berggren

  Bertil B. Fredholm, ASSOCIATE EDITOR

  Pharmacological Reviews April 2013, 65 (2) 641-669; DOI: https://doi.org/10.1124/pr.112.006775
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  Exchange Protein Directly Activated by cAMP (epac): A Multidomain cAMP Mediator in the Regulation of Diverse Biological Functions

  Martina Schmidt, Frank J. Dekker and Harm Maarsingh

  Martin C. Michel, ASSOCIATE EDITOR

  Pharmacological Reviews April 2013, 65 (2) 670-709; DOI: https://doi.org/10.1124/pr.110.003707
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  Nuclear Receptors and Their Selective Pharmacologic Modulators

  Thomas P. Burris, Laura A. Solt, Yongjun Wang, Christine Crumbley, Subhashis Banerjee, Kristine Griffett, Thomas Lundasen, Travis Hughes and Douglas J. Kojetin

  Dianne M. Perez, ASSOCIATE EDITOR

  Pharmacological Reviews April 2013, 65 (2) 710-778; DOI: https://doi.org/10.1124/pr.112.006833
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  Idiosyncratic Adverse Drug Reactions: Current Concepts

  Jack Uetrecht and Dean J. Naisbitt

  Qiang Ma, ASSOCIATE EDITOR

  Pharmacological Reviews April 2013, 65 (2) 779-808; DOI: https://doi.org/10.1124/pr.113.007450
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  A Systematic Comparison of the Properties of Clinically Used Angiotensin II Type 1 Receptor Antagonists

  Martin C. Michel, Carolyn Foster, Hans R. Brunner and Lisheng Liu

  Dianne M. Perez, ASSOCIATE EDITOR

  Pharmacological Reviews April 2013, 65 (2) 809-848; DOI: https://doi.org/10.1124/pr.112.007278
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  Chemical Probes of Endocannabinoid Metabolism

  Jacqueline L. Blankman and Benjamin F. Cravatt

  Eric L. Barker, ASSOCIATE EDITOR

  Pharmacological Reviews April 2013, 65 (2) 849-871; DOI: https://doi.org/10.1124/pr.112.006387