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A Systematic Comparison of the Properties of Clinically Used Angiotensin II Type 1 Receptor Antagonists

Martin C. Michel, Carolyn Foster, Hans R. Brunner and Lisheng Liu
Dianne M. Perez, ASSOCIATE EDITOR
Pharmacological Reviews April 2013, 65 (2) 809-848; DOI: https://doi.org/10.1124/pr.112.007278
Martin C. Michel
Department of Clinical Development & Medical Affairs, Boehringer Ingelheim, Ingelheim, Germany (M.C.M.); Department of Pharmacology, Johannes Gutenberg University, Mainz, Germany (M.C.M.); Department of Research Networking, Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, Connecticut (C.F.); Emeritus of Lausanne University, Riehen, Switzerland (H.R.B.); and Beijing Hypertension League Institute, Fu Wai Hospital, Beijing, China (L.L.)
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Carolyn Foster
Department of Clinical Development & Medical Affairs, Boehringer Ingelheim, Ingelheim, Germany (M.C.M.); Department of Pharmacology, Johannes Gutenberg University, Mainz, Germany (M.C.M.); Department of Research Networking, Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, Connecticut (C.F.); Emeritus of Lausanne University, Riehen, Switzerland (H.R.B.); and Beijing Hypertension League Institute, Fu Wai Hospital, Beijing, China (L.L.)
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Hans R. Brunner
Department of Clinical Development & Medical Affairs, Boehringer Ingelheim, Ingelheim, Germany (M.C.M.); Department of Pharmacology, Johannes Gutenberg University, Mainz, Germany (M.C.M.); Department of Research Networking, Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, Connecticut (C.F.); Emeritus of Lausanne University, Riehen, Switzerland (H.R.B.); and Beijing Hypertension League Institute, Fu Wai Hospital, Beijing, China (L.L.)
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Lisheng Liu
Department of Clinical Development & Medical Affairs, Boehringer Ingelheim, Ingelheim, Germany (M.C.M.); Department of Pharmacology, Johannes Gutenberg University, Mainz, Germany (M.C.M.); Department of Research Networking, Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, Connecticut (C.F.); Emeritus of Lausanne University, Riehen, Switzerland (H.R.B.); and Beijing Hypertension League Institute, Fu Wai Hospital, Beijing, China (L.L.)
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Dianne M. Perez
Department of Clinical Development & Medical Affairs, Boehringer Ingelheim, Ingelheim, Germany (M.C.M.); Department of Pharmacology, Johannes Gutenberg University, Mainz, Germany (M.C.M.); Department of Research Networking, Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, Connecticut (C.F.); Emeritus of Lausanne University, Riehen, Switzerland (H.R.B.); and Beijing Hypertension League Institute, Fu Wai Hospital, Beijing, China (L.L.)
Roles: ASSOCIATE EDITOR
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In this issue

Pharmacological Reviews: 65 (2)
Pharmacological Reviews
Vol. 65, Issue 2
1 Apr 2013
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Review ArticleReview Articles

AT1 Receptor Blocker Pharmacology

Martin C. Michel, Carolyn Foster, Hans R. Brunner and Lisheng Liu
Pharmacological Reviews April 1, 2013, 65 (2) 809-848; DOI: https://doi.org/10.1124/pr.112.007278

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Review ArticleReview Articles

AT1 Receptor Blocker Pharmacology

Martin C. Michel, Carolyn Foster, Hans R. Brunner and Lisheng Liu
Pharmacological Reviews April 1, 2013, 65 (2) 809-848; DOI: https://doi.org/10.1124/pr.112.007278
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  • Article
    • Abstract
    • I. Introduction
    • II. Physicochemical Properties
    • III. Tissue Distribution
    • IV. Direct AT1R Effects
    • V. Receptor Selectivity and Ancillary Effects
    • VI. Pharmacokinetic Properties
    • VII. Conclusions
    • Acknowledgments
    • Authorship contributions
    • Footnotes
    • Abbreviations
    • References
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