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A Systematic Comparison of the Properties of Clinically Used Angiotensin II Type 1 Receptor Antagonists

Martin C. Michel, Carolyn Foster, Hans R. Brunner and Lisheng Liu
Dianne M. Perez, ASSOCIATE EDITOR
Pharmacological Reviews April 2013, 65 (2) 809-848; DOI: https://doi.org/10.1124/pr.112.007278
Martin C. Michel
Department of Clinical Development & Medical Affairs, Boehringer Ingelheim, Ingelheim, Germany (M.C.M.); Department of Pharmacology, Johannes Gutenberg University, Mainz, Germany (M.C.M.); Department of Research Networking, Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, Connecticut (C.F.); Emeritus of Lausanne University, Riehen, Switzerland (H.R.B.); and Beijing Hypertension League Institute, Fu Wai Hospital, Beijing, China (L.L.)
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Carolyn Foster
Department of Clinical Development & Medical Affairs, Boehringer Ingelheim, Ingelheim, Germany (M.C.M.); Department of Pharmacology, Johannes Gutenberg University, Mainz, Germany (M.C.M.); Department of Research Networking, Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, Connecticut (C.F.); Emeritus of Lausanne University, Riehen, Switzerland (H.R.B.); and Beijing Hypertension League Institute, Fu Wai Hospital, Beijing, China (L.L.)
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Hans R. Brunner
Department of Clinical Development & Medical Affairs, Boehringer Ingelheim, Ingelheim, Germany (M.C.M.); Department of Pharmacology, Johannes Gutenberg University, Mainz, Germany (M.C.M.); Department of Research Networking, Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, Connecticut (C.F.); Emeritus of Lausanne University, Riehen, Switzerland (H.R.B.); and Beijing Hypertension League Institute, Fu Wai Hospital, Beijing, China (L.L.)
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Lisheng Liu
Department of Clinical Development & Medical Affairs, Boehringer Ingelheim, Ingelheim, Germany (M.C.M.); Department of Pharmacology, Johannes Gutenberg University, Mainz, Germany (M.C.M.); Department of Research Networking, Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, Connecticut (C.F.); Emeritus of Lausanne University, Riehen, Switzerland (H.R.B.); and Beijing Hypertension League Institute, Fu Wai Hospital, Beijing, China (L.L.)
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Dianne M. Perez
Department of Clinical Development & Medical Affairs, Boehringer Ingelheim, Ingelheim, Germany (M.C.M.); Department of Pharmacology, Johannes Gutenberg University, Mainz, Germany (M.C.M.); Department of Research Networking, Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, Connecticut (C.F.); Emeritus of Lausanne University, Riehen, Switzerland (H.R.B.); and Beijing Hypertension League Institute, Fu Wai Hospital, Beijing, China (L.L.)
Roles: ASSOCIATE EDITOR
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Article Information

vol. 65 no. 2 809-848
DOI 
https://doi.org/10.1124/pr.112.007278
PubMed 
23487168

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0031-6997
Online ISSN 
1521-0081
History 
  • Published online March 13, 2013.

Copyright & Usage 
Copyright © 2013 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Martin C. Michel,
  2. Carolyn Foster,
  3. Hans R. Brunner, and
  4. Lisheng Liu
  1. Department of Clinical Development & Medical Affairs, Boehringer Ingelheim, Ingelheim, Germany (M.C.M.); Department of Pharmacology, Johannes Gutenberg University, Mainz, Germany (M.C.M.); Department of Research Networking, Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, Connecticut (C.F.); Emeritus of Lausanne University, Riehen, Switzerland (H.R.B.); and Beijing Hypertension League Institute, Fu Wai Hospital, Beijing, China (L.L.)
  1. Dianne M. Perez, ASSOCIATE EDITOR
  1. Author correspondence to:
    Prof. Martin C. Michel, Dept. Clinical Development & Medical Affairs, Boehringer Ingelheim Pharma GmbH & Co KG, Binger Str. 173, 55216 Ingelheim, Germany. E-mail: martin.michel{at}boehringer-ingelheim.com
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Pharmacological Reviews: 65 (2)
Pharmacological Reviews
Vol. 65, Issue 2
1 Apr 2013
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Review ArticleReview Articles

AT1 Receptor Blocker Pharmacology

Martin C. Michel, Carolyn Foster, Hans R. Brunner and Lisheng Liu
Pharmacological Reviews April 1, 2013, 65 (2) 809-848; DOI: https://doi.org/10.1124/pr.112.007278

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Review ArticleReview Articles

AT1 Receptor Blocker Pharmacology

Martin C. Michel, Carolyn Foster, Hans R. Brunner and Lisheng Liu
Pharmacological Reviews April 1, 2013, 65 (2) 809-848; DOI: https://doi.org/10.1124/pr.112.007278
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  • Article
    • Abstract
    • I. Introduction
    • II. Physicochemical Properties
    • III. Tissue Distribution
    • IV. Direct AT1R Effects
    • V. Receptor Selectivity and Ancillary Effects
    • VI. Pharmacokinetic Properties
    • VII. Conclusions
    • Acknowledgments
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