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Review ArticleReview Article

Transporters and Drug-Drug Interactions: Important Determinants of Drug Disposition and Effects

Jörg König, Fabian Müller and Martin F. Fromm
Martin C. Michel, ASSOCIATE EDITOR
Pharmacological Reviews July 2013, 65 (3) 944-966; DOI: https://doi.org/10.1124/pr.113.007518
Jörg König
Institute of Experimental and Clinical Pharmacology and Toxicology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Germany
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Fabian Müller
Institute of Experimental and Clinical Pharmacology and Toxicology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Germany
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Martin F. Fromm
Institute of Experimental and Clinical Pharmacology and Toxicology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Germany
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Martin C. Michel
Institute of Experimental and Clinical Pharmacology and Toxicology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Germany
Roles: ASSOCIATE EDITOR
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Article Information

vol. 65 no. 3 944-966
DOI 
https://doi.org/10.1124/pr.113.007518
PubMed 
23686349

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0031-6997
Online ISSN 
1521-0081
History 
  • Published online May 17, 2013.

Copyright & Usage 
Copyright © 2013 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Jörg König,
  2. Fabian Müller, and
  3. Martin F. Fromm
  1. Institute of Experimental and Clinical Pharmacology and Toxicology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Germany
  1. Martin C. Michel, ASSOCIATE EDITOR
  1. Address correspondence to:
    Dr. Martin F. Fromm, Institute of Experimental and Clinical Pharmacology and Toxicology, Clinical Pharmacology and Clinical Toxicology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Fahrstrasse 17, 91054 Erlangen, Germany. E-mail: martin.fromm{at}pharmakologie.med.uni-erlangen.de
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Pharmacological Reviews: 65 (3)
Pharmacological Reviews
Vol. 65, Issue 3
1 Jul 2013
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Review ArticleReview Article

Transporter-Mediated Drug Interactions

Jörg König, Fabian Müller and Martin F. Fromm
Pharmacological Reviews July 1, 2013, 65 (3) 944-966; DOI: https://doi.org/10.1124/pr.113.007518

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Review ArticleReview Article

Transporter-Mediated Drug Interactions

Jörg König, Fabian Müller and Martin F. Fromm
Pharmacological Reviews July 1, 2013, 65 (3) 944-966; DOI: https://doi.org/10.1124/pr.113.007518
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  • Article
    • Abstract
    • I. Introduction
    • II. Expression and General Function of Uptake and Efflux Transporters
    • III. Drug-Drug Interactions
    • IV. Drug-Food Interactions
    • V. Induction of Uptake and Efflux Transporters
    • VI. Genotype-Dependent Drug-Drug Interactions
    • VII. Transporter-Mediated Drug-Drug Interactions in SPCs
    • VIII. Interplay of Drug Transport and Drug Metabolism
    • IX. Conclusions and Outlook
    • Authorship Contributions
    • Footnotes
    • Abbreviations
    • References
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