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Review ArticleReview Article

Seeking Structural Specificity: Direct Modulation of Pentameric Ligand-Gated Ion Channels by Alcohols and General Anesthetics

Rebecca J. Howard, James R. Trudell and R. Adron Harris
Leslie A. Morrow, ASSOCIATE EDITOR
Pharmacological Reviews April 2014, 66 (2) 396-412; DOI: https://doi.org/10.1124/pr.113.007468
Rebecca J. Howard
Department of Chemistry, Skidmore College, Saratoga Springs, New York (R.J.H.); Department of Anesthesia, Stanford University School of Medicine, Stanford, California (J.R.T.); and Waggoner Center for Alcohol and Addiction Research, The University of Texas at Austin, Austin, Texas (R.A.H.)
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James R. Trudell
Department of Chemistry, Skidmore College, Saratoga Springs, New York (R.J.H.); Department of Anesthesia, Stanford University School of Medicine, Stanford, California (J.R.T.); and Waggoner Center for Alcohol and Addiction Research, The University of Texas at Austin, Austin, Texas (R.A.H.)
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R. Adron Harris
Department of Chemistry, Skidmore College, Saratoga Springs, New York (R.J.H.); Department of Anesthesia, Stanford University School of Medicine, Stanford, California (J.R.T.); and Waggoner Center for Alcohol and Addiction Research, The University of Texas at Austin, Austin, Texas (R.A.H.)
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Leslie A. Morrow
Department of Chemistry, Skidmore College, Saratoga Springs, New York (R.J.H.); Department of Anesthesia, Stanford University School of Medicine, Stanford, California (J.R.T.); and Waggoner Center for Alcohol and Addiction Research, The University of Texas at Austin, Austin, Texas (R.A.H.)
Roles: ASSOCIATE EDITOR
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Article Information

vol. 66 no. 2 396-412
DOI 
https://doi.org/10.1124/pr.113.007468
PubMed 
24515646

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0031-6997
Online ISSN 
1521-0081
History 
  • Published online February 10, 2014.

Copyright & Usage 
Copyright © 2014 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Rebecca J. Howard,
  2. James R. Trudell, and
  3. R. Adron Harris
  1. Department of Chemistry, Skidmore College, Saratoga Springs, New York (R.J.H.); Department of Anesthesia, Stanford University School of Medicine, Stanford, California (J.R.T.); and Waggoner Center for Alcohol and Addiction Research, The University of Texas at Austin, Austin, Texas (R.A.H.)
  1. Leslie A. Morrow, ASSOCIATE EDITOR
  1. Address correspondence to:
    Rebecca J. Howard, Department of Chemistry, Skidmore College, Saratoga Springs, NY 12866. E-mail: rhoward{at}skidmore.edu
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Pharmacological Reviews: 66 (2)
Pharmacological Reviews
Vol. 66, Issue 2
1 Apr 2014
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Review ArticleReview Article

Ligand-Gated Ion Channel Alcohol Sites

Rebecca J. Howard, James R. Trudell and R. Adron Harris
Pharmacological Reviews April 1, 2014, 66 (2) 396-412; DOI: https://doi.org/10.1124/pr.113.007468

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Review ArticleReview Article

Ligand-Gated Ion Channel Alcohol Sites

Rebecca J. Howard, James R. Trudell and R. Adron Harris
Pharmacological Reviews April 1, 2014, 66 (2) 396-412; DOI: https://doi.org/10.1124/pr.113.007468
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  • Article
    • Abstract
    • I. Introduction
    • II. Functional Evidence for Modulation
    • III. The Evolution of Accurate Structural Models
    • IV. Crystallographic Contributions
    • V. From Structure Back to Function
    • Authorship Contributions
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