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Review ArticleReview Article

G Protein–Coupled Receptor Oligomerization Revisited: Functional and Pharmacological Perspectives

Sergi Ferré, Vicent Casadó, Lakshmi A. Devi, Marta Filizola, Ralf Jockers, Martin J. Lohse, Graeme Milligan, Jean-Philippe Pin and Xavier Guitart
Mark P. Mattson, ASSOCIATE EDITOR
Pharmacological Reviews April 2014, 66 (2) 413-434; DOI: https://doi.org/10.1124/pr.113.008052
Sergi Ferré
Integrative Neurobiology Section, National Institute on Drug Addiction, Intramural Research Program, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland (S.F., X.G.); Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Barcelona, Barcelona, Spain (V.C.); Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas, Barcelona, Spain (V.C.); Department of Pharmacology and Systems Therapeutics (L.A.D.) and Department of Structural and Chemical Biology (M.F.), Icahn School of Medicine at Mount Sinai, Mount Sinai, New York; Institut National de la Santé et de la Recherche Médicale, U1016, Institut Cochin, Paris, France (R.J.); Centre National de la Recherche Scientifique Unité Mixte de Recherche 8104, Paris, France (R.J.); Universite Paris Descartes, Sorbone Paris Cite, Paris, France (R.J.); Institute of Pharmacology and Toxicology and Rudolf Virchow Center, University of Würzburg, Würzburg, Germany (M.J.L.); Molecular Pharmacology Group, Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, Scotland, United Kingdom (G.M.); Centre National de la Recherche Scientifique, Unité Mixte de Recherche 5203, Institut de Génomique Fonctionnelle, Université Montpellier, Montpellier, France (J.-P.P.); and Institut National de la Santé et de la Recherche Médicale, U661, Montpellier, France (J.-P.P.)
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Vicent Casadó
Integrative Neurobiology Section, National Institute on Drug Addiction, Intramural Research Program, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland (S.F., X.G.); Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Barcelona, Barcelona, Spain (V.C.); Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas, Barcelona, Spain (V.C.); Department of Pharmacology and Systems Therapeutics (L.A.D.) and Department of Structural and Chemical Biology (M.F.), Icahn School of Medicine at Mount Sinai, Mount Sinai, New York; Institut National de la Santé et de la Recherche Médicale, U1016, Institut Cochin, Paris, France (R.J.); Centre National de la Recherche Scientifique Unité Mixte de Recherche 8104, Paris, France (R.J.); Universite Paris Descartes, Sorbone Paris Cite, Paris, France (R.J.); Institute of Pharmacology and Toxicology and Rudolf Virchow Center, University of Würzburg, Würzburg, Germany (M.J.L.); Molecular Pharmacology Group, Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, Scotland, United Kingdom (G.M.); Centre National de la Recherche Scientifique, Unité Mixte de Recherche 5203, Institut de Génomique Fonctionnelle, Université Montpellier, Montpellier, France (J.-P.P.); and Institut National de la Santé et de la Recherche Médicale, U661, Montpellier, France (J.-P.P.)
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Lakshmi A. Devi
Integrative Neurobiology Section, National Institute on Drug Addiction, Intramural Research Program, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland (S.F., X.G.); Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Barcelona, Barcelona, Spain (V.C.); Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas, Barcelona, Spain (V.C.); Department of Pharmacology and Systems Therapeutics (L.A.D.) and Department of Structural and Chemical Biology (M.F.), Icahn School of Medicine at Mount Sinai, Mount Sinai, New York; Institut National de la Santé et de la Recherche Médicale, U1016, Institut Cochin, Paris, France (R.J.); Centre National de la Recherche Scientifique Unité Mixte de Recherche 8104, Paris, France (R.J.); Universite Paris Descartes, Sorbone Paris Cite, Paris, France (R.J.); Institute of Pharmacology and Toxicology and Rudolf Virchow Center, University of Würzburg, Würzburg, Germany (M.J.L.); Molecular Pharmacology Group, Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, Scotland, United Kingdom (G.M.); Centre National de la Recherche Scientifique, Unité Mixte de Recherche 5203, Institut de Génomique Fonctionnelle, Université Montpellier, Montpellier, France (J.-P.P.); and Institut National de la Santé et de la Recherche Médicale, U661, Montpellier, France (J.-P.P.)
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Marta Filizola
Integrative Neurobiology Section, National Institute on Drug Addiction, Intramural Research Program, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland (S.F., X.G.); Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Barcelona, Barcelona, Spain (V.C.); Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas, Barcelona, Spain (V.C.); Department of Pharmacology and Systems Therapeutics (L.A.D.) and Department of Structural and Chemical Biology (M.F.), Icahn School of Medicine at Mount Sinai, Mount Sinai, New York; Institut National de la Santé et de la Recherche Médicale, U1016, Institut Cochin, Paris, France (R.J.); Centre National de la Recherche Scientifique Unité Mixte de Recherche 8104, Paris, France (R.J.); Universite Paris Descartes, Sorbone Paris Cite, Paris, France (R.J.); Institute of Pharmacology and Toxicology and Rudolf Virchow Center, University of Würzburg, Würzburg, Germany (M.J.L.); Molecular Pharmacology Group, Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, Scotland, United Kingdom (G.M.); Centre National de la Recherche Scientifique, Unité Mixte de Recherche 5203, Institut de Génomique Fonctionnelle, Université Montpellier, Montpellier, France (J.-P.P.); and Institut National de la Santé et de la Recherche Médicale, U661, Montpellier, France (J.-P.P.)
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Ralf Jockers
Integrative Neurobiology Section, National Institute on Drug Addiction, Intramural Research Program, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland (S.F., X.G.); Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Barcelona, Barcelona, Spain (V.C.); Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas, Barcelona, Spain (V.C.); Department of Pharmacology and Systems Therapeutics (L.A.D.) and Department of Structural and Chemical Biology (M.F.), Icahn School of Medicine at Mount Sinai, Mount Sinai, New York; Institut National de la Santé et de la Recherche Médicale, U1016, Institut Cochin, Paris, France (R.J.); Centre National de la Recherche Scientifique Unité Mixte de Recherche 8104, Paris, France (R.J.); Universite Paris Descartes, Sorbone Paris Cite, Paris, France (R.J.); Institute of Pharmacology and Toxicology and Rudolf Virchow Center, University of Würzburg, Würzburg, Germany (M.J.L.); Molecular Pharmacology Group, Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, Scotland, United Kingdom (G.M.); Centre National de la Recherche Scientifique, Unité Mixte de Recherche 5203, Institut de Génomique Fonctionnelle, Université Montpellier, Montpellier, France (J.-P.P.); and Institut National de la Santé et de la Recherche Médicale, U661, Montpellier, France (J.-P.P.)
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Martin J. Lohse
Integrative Neurobiology Section, National Institute on Drug Addiction, Intramural Research Program, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland (S.F., X.G.); Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Barcelona, Barcelona, Spain (V.C.); Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas, Barcelona, Spain (V.C.); Department of Pharmacology and Systems Therapeutics (L.A.D.) and Department of Structural and Chemical Biology (M.F.), Icahn School of Medicine at Mount Sinai, Mount Sinai, New York; Institut National de la Santé et de la Recherche Médicale, U1016, Institut Cochin, Paris, France (R.J.); Centre National de la Recherche Scientifique Unité Mixte de Recherche 8104, Paris, France (R.J.); Universite Paris Descartes, Sorbone Paris Cite, Paris, France (R.J.); Institute of Pharmacology and Toxicology and Rudolf Virchow Center, University of Würzburg, Würzburg, Germany (M.J.L.); Molecular Pharmacology Group, Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, Scotland, United Kingdom (G.M.); Centre National de la Recherche Scientifique, Unité Mixte de Recherche 5203, Institut de Génomique Fonctionnelle, Université Montpellier, Montpellier, France (J.-P.P.); and Institut National de la Santé et de la Recherche Médicale, U661, Montpellier, France (J.-P.P.)
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Graeme Milligan
Integrative Neurobiology Section, National Institute on Drug Addiction, Intramural Research Program, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland (S.F., X.G.); Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Barcelona, Barcelona, Spain (V.C.); Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas, Barcelona, Spain (V.C.); Department of Pharmacology and Systems Therapeutics (L.A.D.) and Department of Structural and Chemical Biology (M.F.), Icahn School of Medicine at Mount Sinai, Mount Sinai, New York; Institut National de la Santé et de la Recherche Médicale, U1016, Institut Cochin, Paris, France (R.J.); Centre National de la Recherche Scientifique Unité Mixte de Recherche 8104, Paris, France (R.J.); Universite Paris Descartes, Sorbone Paris Cite, Paris, France (R.J.); Institute of Pharmacology and Toxicology and Rudolf Virchow Center, University of Würzburg, Würzburg, Germany (M.J.L.); Molecular Pharmacology Group, Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, Scotland, United Kingdom (G.M.); Centre National de la Recherche Scientifique, Unité Mixte de Recherche 5203, Institut de Génomique Fonctionnelle, Université Montpellier, Montpellier, France (J.-P.P.); and Institut National de la Santé et de la Recherche Médicale, U661, Montpellier, France (J.-P.P.)
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Jean-Philippe Pin
Integrative Neurobiology Section, National Institute on Drug Addiction, Intramural Research Program, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland (S.F., X.G.); Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Barcelona, Barcelona, Spain (V.C.); Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas, Barcelona, Spain (V.C.); Department of Pharmacology and Systems Therapeutics (L.A.D.) and Department of Structural and Chemical Biology (M.F.), Icahn School of Medicine at Mount Sinai, Mount Sinai, New York; Institut National de la Santé et de la Recherche Médicale, U1016, Institut Cochin, Paris, France (R.J.); Centre National de la Recherche Scientifique Unité Mixte de Recherche 8104, Paris, France (R.J.); Universite Paris Descartes, Sorbone Paris Cite, Paris, France (R.J.); Institute of Pharmacology and Toxicology and Rudolf Virchow Center, University of Würzburg, Würzburg, Germany (M.J.L.); Molecular Pharmacology Group, Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, Scotland, United Kingdom (G.M.); Centre National de la Recherche Scientifique, Unité Mixte de Recherche 5203, Institut de Génomique Fonctionnelle, Université Montpellier, Montpellier, France (J.-P.P.); and Institut National de la Santé et de la Recherche Médicale, U661, Montpellier, France (J.-P.P.)
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Xavier Guitart
Integrative Neurobiology Section, National Institute on Drug Addiction, Intramural Research Program, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland (S.F., X.G.); Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Barcelona, Barcelona, Spain (V.C.); Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas, Barcelona, Spain (V.C.); Department of Pharmacology and Systems Therapeutics (L.A.D.) and Department of Structural and Chemical Biology (M.F.), Icahn School of Medicine at Mount Sinai, Mount Sinai, New York; Institut National de la Santé et de la Recherche Médicale, U1016, Institut Cochin, Paris, France (R.J.); Centre National de la Recherche Scientifique Unité Mixte de Recherche 8104, Paris, France (R.J.); Universite Paris Descartes, Sorbone Paris Cite, Paris, France (R.J.); Institute of Pharmacology and Toxicology and Rudolf Virchow Center, University of Würzburg, Würzburg, Germany (M.J.L.); Molecular Pharmacology Group, Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, Scotland, United Kingdom (G.M.); Centre National de la Recherche Scientifique, Unité Mixte de Recherche 5203, Institut de Génomique Fonctionnelle, Université Montpellier, Montpellier, France (J.-P.P.); and Institut National de la Santé et de la Recherche Médicale, U661, Montpellier, France (J.-P.P.)
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Mark P. Mattson
Integrative Neurobiology Section, National Institute on Drug Addiction, Intramural Research Program, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland (S.F., X.G.); Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Barcelona, Barcelona, Spain (V.C.); Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas, Barcelona, Spain (V.C.); Department of Pharmacology and Systems Therapeutics (L.A.D.) and Department of Structural and Chemical Biology (M.F.), Icahn School of Medicine at Mount Sinai, Mount Sinai, New York; Institut National de la Santé et de la Recherche Médicale, U1016, Institut Cochin, Paris, France (R.J.); Centre National de la Recherche Scientifique Unité Mixte de Recherche 8104, Paris, France (R.J.); Universite Paris Descartes, Sorbone Paris Cite, Paris, France (R.J.); Institute of Pharmacology and Toxicology and Rudolf Virchow Center, University of Würzburg, Würzburg, Germany (M.J.L.); Molecular Pharmacology Group, Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, Scotland, United Kingdom (G.M.); Centre National de la Recherche Scientifique, Unité Mixte de Recherche 5203, Institut de Génomique Fonctionnelle, Université Montpellier, Montpellier, France (J.-P.P.); and Institut National de la Santé et de la Recherche Médicale, U661, Montpellier, France (J.-P.P.)
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Pharmacological Reviews: 66 (2)
Pharmacological Reviews
Vol. 66, Issue 2
1 Apr 2014
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Review ArticleReview Article

G Protein–Coupled Receptor Oligomerization

Sergi Ferré, Vicent Casadó, Lakshmi A. Devi, Marta Filizola, Ralf Jockers, Martin J. Lohse, Graeme Milligan, Jean-Philippe Pin and Xavier Guitart
Pharmacological Reviews April 1, 2014, 66 (2) 413-434; DOI: https://doi.org/10.1124/pr.113.008052

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Review ArticleReview Article

G Protein–Coupled Receptor Oligomerization

Sergi Ferré, Vicent Casadó, Lakshmi A. Devi, Marta Filizola, Ralf Jockers, Martin J. Lohse, Graeme Milligan, Jean-Philippe Pin and Xavier Guitart
Pharmacological Reviews April 1, 2014, 66 (2) 413-434; DOI: https://doi.org/10.1124/pr.113.008052
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    • Abstract
    • I. Morphologic Aspects of G Protein–Coupled Receptor Oligomerization
    • II. Functional Aspects of G Protein–Coupled Receptor Oligomerization
    • III. G Protein–Coupled Receptor Oligomers as Novel Targets for Drug Development
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