Review ArticleReview Article
Antitussive Drugs—Past, Present, and Future
P.V. Dicpinigaitis, A.H. Morice, S.S. Birring, L. McGarvey, J.A. Smith, B.J. Canning and C.P. Page
David R. Sibley, ASSOCIATE EDITOR
Pharmacological Reviews April 2014, 66 (2) 468-512; DOI: https://doi.org/10.1124/pr.111.005116
P.V. Dicpinigaitis
Albert Einstein College of Medicine and Montefiore Medical Centre, Department of Medicine, Bronx, New York (P.V.D);Centre for Cardiovascular and Metabolic Medicine, Castle Hill Hospital, Hull York Medical School, University of Hull, Hull, United Kingdom (A.H.M.); Division of Asthma, Allergy & Lung Biology, King’s College London, Denmark Hill, London, United Kingdom (S.S.B.); Centre for Infection and Immunity, Queen's University Belfast, Belfast, United Kingdom (L.M.); Respiratory Research Group, University of Manchester, University Hospital of South Manchester, Manchester, United Kingdom (J.A.S.); Johns Hopkins Asthma and Allergy Center, Baltimore, Maryland (B.J.C.); and Sackler Institute of Pulmonary Pharmacology, Institute of Pharmaceutical Science, King’s College London, Franklin-Wilkins Building, London, United Kingdom (C.P.P.)
A.H. Morice
Albert Einstein College of Medicine and Montefiore Medical Centre, Department of Medicine, Bronx, New York (P.V.D);Centre for Cardiovascular and Metabolic Medicine, Castle Hill Hospital, Hull York Medical School, University of Hull, Hull, United Kingdom (A.H.M.); Division of Asthma, Allergy & Lung Biology, King’s College London, Denmark Hill, London, United Kingdom (S.S.B.); Centre for Infection and Immunity, Queen's University Belfast, Belfast, United Kingdom (L.M.); Respiratory Research Group, University of Manchester, University Hospital of South Manchester, Manchester, United Kingdom (J.A.S.); Johns Hopkins Asthma and Allergy Center, Baltimore, Maryland (B.J.C.); and Sackler Institute of Pulmonary Pharmacology, Institute of Pharmaceutical Science, King’s College London, Franklin-Wilkins Building, London, United Kingdom (C.P.P.)
S.S. Birring
Albert Einstein College of Medicine and Montefiore Medical Centre, Department of Medicine, Bronx, New York (P.V.D);Centre for Cardiovascular and Metabolic Medicine, Castle Hill Hospital, Hull York Medical School, University of Hull, Hull, United Kingdom (A.H.M.); Division of Asthma, Allergy & Lung Biology, King’s College London, Denmark Hill, London, United Kingdom (S.S.B.); Centre for Infection and Immunity, Queen's University Belfast, Belfast, United Kingdom (L.M.); Respiratory Research Group, University of Manchester, University Hospital of South Manchester, Manchester, United Kingdom (J.A.S.); Johns Hopkins Asthma and Allergy Center, Baltimore, Maryland (B.J.C.); and Sackler Institute of Pulmonary Pharmacology, Institute of Pharmaceutical Science, King’s College London, Franklin-Wilkins Building, London, United Kingdom (C.P.P.)
L. McGarvey
Albert Einstein College of Medicine and Montefiore Medical Centre, Department of Medicine, Bronx, New York (P.V.D);Centre for Cardiovascular and Metabolic Medicine, Castle Hill Hospital, Hull York Medical School, University of Hull, Hull, United Kingdom (A.H.M.); Division of Asthma, Allergy & Lung Biology, King’s College London, Denmark Hill, London, United Kingdom (S.S.B.); Centre for Infection and Immunity, Queen's University Belfast, Belfast, United Kingdom (L.M.); Respiratory Research Group, University of Manchester, University Hospital of South Manchester, Manchester, United Kingdom (J.A.S.); Johns Hopkins Asthma and Allergy Center, Baltimore, Maryland (B.J.C.); and Sackler Institute of Pulmonary Pharmacology, Institute of Pharmaceutical Science, King’s College London, Franklin-Wilkins Building, London, United Kingdom (C.P.P.)
J.A. Smith
Albert Einstein College of Medicine and Montefiore Medical Centre, Department of Medicine, Bronx, New York (P.V.D);Centre for Cardiovascular and Metabolic Medicine, Castle Hill Hospital, Hull York Medical School, University of Hull, Hull, United Kingdom (A.H.M.); Division of Asthma, Allergy & Lung Biology, King’s College London, Denmark Hill, London, United Kingdom (S.S.B.); Centre for Infection and Immunity, Queen's University Belfast, Belfast, United Kingdom (L.M.); Respiratory Research Group, University of Manchester, University Hospital of South Manchester, Manchester, United Kingdom (J.A.S.); Johns Hopkins Asthma and Allergy Center, Baltimore, Maryland (B.J.C.); and Sackler Institute of Pulmonary Pharmacology, Institute of Pharmaceutical Science, King’s College London, Franklin-Wilkins Building, London, United Kingdom (C.P.P.)
B.J. Canning
Albert Einstein College of Medicine and Montefiore Medical Centre, Department of Medicine, Bronx, New York (P.V.D);Centre for Cardiovascular and Metabolic Medicine, Castle Hill Hospital, Hull York Medical School, University of Hull, Hull, United Kingdom (A.H.M.); Division of Asthma, Allergy & Lung Biology, King’s College London, Denmark Hill, London, United Kingdom (S.S.B.); Centre for Infection and Immunity, Queen's University Belfast, Belfast, United Kingdom (L.M.); Respiratory Research Group, University of Manchester, University Hospital of South Manchester, Manchester, United Kingdom (J.A.S.); Johns Hopkins Asthma and Allergy Center, Baltimore, Maryland (B.J.C.); and Sackler Institute of Pulmonary Pharmacology, Institute of Pharmaceutical Science, King’s College London, Franklin-Wilkins Building, London, United Kingdom (C.P.P.)
C.P. Page
Albert Einstein College of Medicine and Montefiore Medical Centre, Department of Medicine, Bronx, New York (P.V.D);Centre for Cardiovascular and Metabolic Medicine, Castle Hill Hospital, Hull York Medical School, University of Hull, Hull, United Kingdom (A.H.M.); Division of Asthma, Allergy & Lung Biology, King’s College London, Denmark Hill, London, United Kingdom (S.S.B.); Centre for Infection and Immunity, Queen's University Belfast, Belfast, United Kingdom (L.M.); Respiratory Research Group, University of Manchester, University Hospital of South Manchester, Manchester, United Kingdom (J.A.S.); Johns Hopkins Asthma and Allergy Center, Baltimore, Maryland (B.J.C.); and Sackler Institute of Pulmonary Pharmacology, Institute of Pharmaceutical Science, King’s College London, Franklin-Wilkins Building, London, United Kingdom (C.P.P.)
David R. Sibley
Albert Einstein College of Medicine and Montefiore Medical Centre, Department of Medicine, Bronx, New York (P.V.D);Centre for Cardiovascular and Metabolic Medicine, Castle Hill Hospital, Hull York Medical School, University of Hull, Hull, United Kingdom (A.H.M.); Division of Asthma, Allergy & Lung Biology, King’s College London, Denmark Hill, London, United Kingdom (S.S.B.); Centre for Infection and Immunity, Queen's University Belfast, Belfast, United Kingdom (L.M.); Respiratory Research Group, University of Manchester, University Hospital of South Manchester, Manchester, United Kingdom (J.A.S.); Johns Hopkins Asthma and Allergy Center, Baltimore, Maryland (B.J.C.); and Sackler Institute of Pulmonary Pharmacology, Institute of Pharmaceutical Science, King’s College London, Franklin-Wilkins Building, London, United Kingdom (C.P.P.)
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In this issue
Review ArticleReview Article
Antitussive Drugs
P.V. Dicpinigaitis, A.H. Morice, S.S. Birring, L. McGarvey, J.A. Smith, B.J. Canning and C.P. Page
Pharmacological Reviews April 1, 2014, 66 (2) 468-512; DOI: https://doi.org/10.1124/pr.111.005116
Jump to section
- Article
- Abstract
- I. Cough as an Unmet Clinical Problem
- II. Basic Physiology of the Cough Reflex
- III. Drugs in Current Use for the Treatment of Cough
- IV. Other Drugs Having an Effect on Cough
- V. New Approaches to Treating Cough
- VI. Clinical Trial Design for Evaluation of Antitussive Drugs
- VII. Conclusions—What’s Needed
- Footnotes
- Abbreviations
- References
- Figures & Data
- Info & Metrics
- eLetters
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