Research ArticleReview Article
The P2X7 Receptor Channel: Recent Developments and the Use of P2X7 Antagonists in Models of Disease
Rachael Bartlett, Leanne Stokes and Ronald Sluyter
David R. Sibley, ASSOCIATE EDITOR
Pharmacological Reviews July 2014, 66 (3) 638-675; DOI: https://doi.org/10.1124/pr.113.008003
Rachael Bartlett
School of Biological Sciences, University of Wollongong, New South Wales, Australia and Illawarra Health and Medical Research Institute, Wollongong, New South Wales, Australia (R.B., R.S.); and Health Innovations Research Institute, School of Medical Sciences, RMIT University, Bundoora, Victoria, Australia (L.S.)
Leanne Stokes
School of Biological Sciences, University of Wollongong, New South Wales, Australia and Illawarra Health and Medical Research Institute, Wollongong, New South Wales, Australia (R.B., R.S.); and Health Innovations Research Institute, School of Medical Sciences, RMIT University, Bundoora, Victoria, Australia (L.S.)
Ronald Sluyter
School of Biological Sciences, University of Wollongong, New South Wales, Australia and Illawarra Health and Medical Research Institute, Wollongong, New South Wales, Australia (R.B., R.S.); and Health Innovations Research Institute, School of Medical Sciences, RMIT University, Bundoora, Victoria, Australia (L.S.)
David R. Sibley
School of Biological Sciences, University of Wollongong, New South Wales, Australia and Illawarra Health and Medical Research Institute, Wollongong, New South Wales, Australia (R.B., R.S.); and Health Innovations Research Institute, School of Medical Sciences, RMIT University, Bundoora, Victoria, Australia (L.S.)
Roles: ASSOCIATE EDITOR
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In this issue
Research ArticleReview Article
P2X7 Antagonists in Models of Disease
Rachael Bartlett, Leanne Stokes and Ronald Sluyter
Pharmacological Reviews July 1, 2014, 66 (3) 638-675; DOI: https://doi.org/10.1124/pr.113.008003
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- Article
- Abstract
- I. The P2X7 Receptor
- II. The Rodent P2X7 Receptor
- III. The Human P2X7 Receptor
- IV. P2X7 Receptors of Other Mammalian Species
- V. Gating of the P2X7 Receptor Channel
- VI. Permeability of the P2X7 Receptor
- VII. P2X7 Receptor-Dependent Signaling Pathways
- VIII. Variants of the P2X7 Receptor
- IX. Modulators of P2X7 Receptor Activation
- X. Use of Modulators of P2X7 Receptor In Vivo
- XI. P2X7 Antagonists in Human Clinical Trials
- XII. Modulators of P2X7 Receptor Expression
- XIII. Conclusions and Future Directions
- Acknowledgments
- Authorship Contributions
- Footnotes
- Abbreviations
- References
- Figures & Data
- Info & Metrics
- eLetters
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