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Research ArticleReview Article

Intracranial Self-Stimulation to Evaluate Abuse Potential of Drugs

S. Stevens Negus and Laurence L. Miller
Michael A. Nader, ASSOCIATE EDITOR
Pharmacological Reviews July 2014, 66 (3) 869-917; DOI: https://doi.org/10.1124/pr.112.007419
S. Stevens Negus
Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, Virginia
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Laurence L. Miller
Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, Virginia
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Michael A. Nader
Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, Virginia
Roles: ASSOCIATE EDITOR
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Article Information

vol. 66 no. 3 869-917
DOI 
https://doi.org/10.1124/pr.112.007419
PubMed 
24973197

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0031-6997
Online ISSN 
1521-0081
History 
  • Published online June 27, 2014.

Copyright & Usage 
Copyright © 2014 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. S. Stevens Negus and
  2. Laurence L. Miller
  1. Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, Virginia
  1. Michael A. Nader, ASSOCIATE EDITOR
  1. Address correspondence to:
    S. Stevens Negus, Department of Pharmacology and Toxicology, 410 N. 12th St., Richmond, VA 23298. E-mail: ssnegus{at}vcu.edu
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In this issue

Pharmacological Reviews: 66 (3)
Pharmacological Reviews
Vol. 66, Issue 3
1 Jul 2014
  • Table of Contents
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Research ArticleReview Article

ICSS in Abuse Potential Testing

S. Stevens Negus and Laurence L. Miller
Pharmacological Reviews July 1, 2014, 66 (3) 869-917; DOI: https://doi.org/10.1124/pr.112.007419

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Research ArticleReview Article

ICSS in Abuse Potential Testing

S. Stevens Negus and Laurence L. Miller
Pharmacological Reviews July 1, 2014, 66 (3) 869-917; DOI: https://doi.org/10.1124/pr.112.007419
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  • Article
    • Abstract
    • I. Introduction to Abuse Potential Testing
    • II. Intracranial Self-Stimulation Methodology
    • III. Drug Effects on Intracranial Self-Stimulation by Drug Class
    • IV. State and Trait as Determinants of Drug Effects on Intracranial Self-Stimulation
    • V. Predictive Validity of Intracranial Self-Stimulation in Abuse Potential Testing
    • VI. Conclusions and Future Directions
    • Acknowledgments
    • Authorship Contributions
    • Footnotes
    • Abbreviations
    • References
  • Figures & Data
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