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Review ArticleReview Article

Phospholipase D Signaling Pathways and Phosphatidic Acid as Therapeutic Targets in Cancer

Ronald C. Bruntz, Craig W. Lindsley and H. Alex Brown
David R. Sibley, ASSOCIATE EDITOR
Pharmacological Reviews October 2014, 66 (4) 1033-1079; DOI: https://doi.org/10.1124/pr.114.009217
Ronald C. Bruntz
Department of Pharmacology (R.C.B., C.W.L., H.A.B.) and Vanderbilt Center for Neuroscience Drug Discovery (C.W.L.), Vanderbilt University Medical Center; Department of Chemistry, Vanderbilt Institute of Chemical Biology (C.W.L., H.A.B.); Vanderbilt Specialized Chemistry for Accelerated Probe Development (C.W.L.); and Department of Biochemistry, Vanderbilt-Ingram Cancer Center (H.A.B.), Vanderbilt University, Nashville, Tennessee
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Craig W. Lindsley
Department of Pharmacology (R.C.B., C.W.L., H.A.B.) and Vanderbilt Center for Neuroscience Drug Discovery (C.W.L.), Vanderbilt University Medical Center; Department of Chemistry, Vanderbilt Institute of Chemical Biology (C.W.L., H.A.B.); Vanderbilt Specialized Chemistry for Accelerated Probe Development (C.W.L.); and Department of Biochemistry, Vanderbilt-Ingram Cancer Center (H.A.B.), Vanderbilt University, Nashville, Tennessee
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H. Alex Brown
Department of Pharmacology (R.C.B., C.W.L., H.A.B.) and Vanderbilt Center for Neuroscience Drug Discovery (C.W.L.), Vanderbilt University Medical Center; Department of Chemistry, Vanderbilt Institute of Chemical Biology (C.W.L., H.A.B.); Vanderbilt Specialized Chemistry for Accelerated Probe Development (C.W.L.); and Department of Biochemistry, Vanderbilt-Ingram Cancer Center (H.A.B.), Vanderbilt University, Nashville, Tennessee
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David R. Sibley
Department of Pharmacology (R.C.B., C.W.L., H.A.B.) and Vanderbilt Center for Neuroscience Drug Discovery (C.W.L.), Vanderbilt University Medical Center; Department of Chemistry, Vanderbilt Institute of Chemical Biology (C.W.L., H.A.B.); Vanderbilt Specialized Chemistry for Accelerated Probe Development (C.W.L.); and Department of Biochemistry, Vanderbilt-Ingram Cancer Center (H.A.B.), Vanderbilt University, Nashville, Tennessee
Roles: ASSOCIATE EDITOR
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In this issue

Pharmacological Reviews: 66 (4)
Pharmacological Reviews
Vol. 66, Issue 4
1 Oct 2014
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Review ArticleReview Article

PLD and Phosphatidic Acid in Cancer

Ronald C. Bruntz, Craig W. Lindsley and H. Alex Brown
Pharmacological Reviews October 1, 2014, 66 (4) 1033-1079; DOI: https://doi.org/10.1124/pr.114.009217

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Review ArticleReview Article

PLD and Phosphatidic Acid in Cancer

Ronald C. Bruntz, Craig W. Lindsley and H. Alex Brown
Pharmacological Reviews October 1, 2014, 66 (4) 1033-1079; DOI: https://doi.org/10.1124/pr.114.009217
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  • Article
    • Abstract
    • I. Background
    • II. Regulation of Phospholipase D Activity by Lipids
    • III. Phosphorylation
    • IV. Protein Activators of Phospholipase D
    • V. Phospholipase D Inhibitory Proteins
    • VI. Cell Surface Receptor Regulation of Phospholipase D
    • VII. Functions of Phospholipase D Contributing to Cancer
    • VIII. Phospholipase D Small-Molecule Inhibitors
    • IX. Functions of Phosphatidic Acid
    • X. Closing Points
    • Acknowledgments
    • Authorship Contributions
    • Footnotes
    • Abbreviations
    • References
  • Figures & Data
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