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Review ArticleReview Article

Phospholipase D Signaling Pathways and Phosphatidic Acid as Therapeutic Targets in Cancer

Ronald C. Bruntz, Craig W. Lindsley and H. Alex Brown
David R. Sibley, ASSOCIATE EDITOR
Pharmacological Reviews October 2014, 66 (4) 1033-1079; DOI: https://doi.org/10.1124/pr.114.009217
Ronald C. Bruntz
Department of Pharmacology (R.C.B., C.W.L., H.A.B.) and Vanderbilt Center for Neuroscience Drug Discovery (C.W.L.), Vanderbilt University Medical Center; Department of Chemistry, Vanderbilt Institute of Chemical Biology (C.W.L., H.A.B.); Vanderbilt Specialized Chemistry for Accelerated Probe Development (C.W.L.); and Department of Biochemistry, Vanderbilt-Ingram Cancer Center (H.A.B.), Vanderbilt University, Nashville, Tennessee
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Craig W. Lindsley
Department of Pharmacology (R.C.B., C.W.L., H.A.B.) and Vanderbilt Center for Neuroscience Drug Discovery (C.W.L.), Vanderbilt University Medical Center; Department of Chemistry, Vanderbilt Institute of Chemical Biology (C.W.L., H.A.B.); Vanderbilt Specialized Chemistry for Accelerated Probe Development (C.W.L.); and Department of Biochemistry, Vanderbilt-Ingram Cancer Center (H.A.B.), Vanderbilt University, Nashville, Tennessee
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H. Alex Brown
Department of Pharmacology (R.C.B., C.W.L., H.A.B.) and Vanderbilt Center for Neuroscience Drug Discovery (C.W.L.), Vanderbilt University Medical Center; Department of Chemistry, Vanderbilt Institute of Chemical Biology (C.W.L., H.A.B.); Vanderbilt Specialized Chemistry for Accelerated Probe Development (C.W.L.); and Department of Biochemistry, Vanderbilt-Ingram Cancer Center (H.A.B.), Vanderbilt University, Nashville, Tennessee
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David R. Sibley
Department of Pharmacology (R.C.B., C.W.L., H.A.B.) and Vanderbilt Center for Neuroscience Drug Discovery (C.W.L.), Vanderbilt University Medical Center; Department of Chemistry, Vanderbilt Institute of Chemical Biology (C.W.L., H.A.B.); Vanderbilt Specialized Chemistry for Accelerated Probe Development (C.W.L.); and Department of Biochemistry, Vanderbilt-Ingram Cancer Center (H.A.B.), Vanderbilt University, Nashville, Tennessee
Roles: ASSOCIATE EDITOR
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Article Information

vol. 66 no. 4 1033-1079
DOI 
https://doi.org/10.1124/pr.114.009217
PubMed 
25244928

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0031-6997
Online ISSN 
1521-0081
History 
  • Published online September 22, 2014.

Copyright & Usage 
Copyright © 2014 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Ronald C. Bruntz,
  2. Craig W. Lindsley, and
  3. H. Alex Brown
  1. Department of Pharmacology (R.C.B., C.W.L., H.A.B.) and Vanderbilt Center for Neuroscience Drug Discovery (C.W.L.), Vanderbilt University Medical Center; Department of Chemistry, Vanderbilt Institute of Chemical Biology (C.W.L., H.A.B.); Vanderbilt Specialized Chemistry for Accelerated Probe Development (C.W.L.); and Department of Biochemistry, Vanderbilt-Ingram Cancer Center (H.A.B.), Vanderbilt University, Nashville, Tennessee
  1. David R. Sibley, ASSOCIATE EDITOR
  1. Address correspondence to:
    Dr. H. Alex Brown, Vanderbilt University School of Medicine, 2220 Pierce Avenue South, Nashville, TN 37232-6600. E-mail: alex.brown{at}Vanderbilt.edu
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Pharmacological Reviews: 66 (4)
Pharmacological Reviews
Vol. 66, Issue 4
1 Oct 2014
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Review ArticleReview Article

PLD and Phosphatidic Acid in Cancer

Ronald C. Bruntz, Craig W. Lindsley and H. Alex Brown
Pharmacological Reviews October 1, 2014, 66 (4) 1033-1079; DOI: https://doi.org/10.1124/pr.114.009217

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Review ArticleReview Article

PLD and Phosphatidic Acid in Cancer

Ronald C. Bruntz, Craig W. Lindsley and H. Alex Brown
Pharmacological Reviews October 1, 2014, 66 (4) 1033-1079; DOI: https://doi.org/10.1124/pr.114.009217
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  • Article
    • Abstract
    • I. Background
    • II. Regulation of Phospholipase D Activity by Lipids
    • III. Phosphorylation
    • IV. Protein Activators of Phospholipase D
    • V. Phospholipase D Inhibitory Proteins
    • VI. Cell Surface Receptor Regulation of Phospholipase D
    • VII. Functions of Phospholipase D Contributing to Cancer
    • VIII. Phospholipase D Small-Molecule Inhibitors
    • IX. Functions of Phosphatidic Acid
    • X. Closing Points
    • Acknowledgments
    • Authorship Contributions
    • Footnotes
    • Abbreviations
    • References
  • Figures & Data
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