Review ArticleReview Article
Phospholipase D Signaling Pathways and Phosphatidic Acid as Therapeutic Targets in Cancer
Ronald C. Bruntz, Craig W. Lindsley and H. Alex Brown
David R. Sibley, ASSOCIATE EDITOR
Pharmacological Reviews October 2014, 66 (4) 1033-1079; DOI: https://doi.org/10.1124/pr.114.009217
Ronald C. Bruntz
Department of Pharmacology (R.C.B., C.W.L., H.A.B.) and Vanderbilt Center for Neuroscience Drug Discovery (C.W.L.), Vanderbilt University Medical Center; Department of Chemistry, Vanderbilt Institute of Chemical Biology (C.W.L., H.A.B.); Vanderbilt Specialized Chemistry for Accelerated Probe Development (C.W.L.); and Department of Biochemistry, Vanderbilt-Ingram Cancer Center (H.A.B.), Vanderbilt University, Nashville, Tennessee
Craig W. Lindsley
Department of Pharmacology (R.C.B., C.W.L., H.A.B.) and Vanderbilt Center for Neuroscience Drug Discovery (C.W.L.), Vanderbilt University Medical Center; Department of Chemistry, Vanderbilt Institute of Chemical Biology (C.W.L., H.A.B.); Vanderbilt Specialized Chemistry for Accelerated Probe Development (C.W.L.); and Department of Biochemistry, Vanderbilt-Ingram Cancer Center (H.A.B.), Vanderbilt University, Nashville, Tennessee
H. Alex Brown
Department of Pharmacology (R.C.B., C.W.L., H.A.B.) and Vanderbilt Center for Neuroscience Drug Discovery (C.W.L.), Vanderbilt University Medical Center; Department of Chemistry, Vanderbilt Institute of Chemical Biology (C.W.L., H.A.B.); Vanderbilt Specialized Chemistry for Accelerated Probe Development (C.W.L.); and Department of Biochemistry, Vanderbilt-Ingram Cancer Center (H.A.B.), Vanderbilt University, Nashville, Tennessee
David R. Sibley
Department of Pharmacology (R.C.B., C.W.L., H.A.B.) and Vanderbilt Center for Neuroscience Drug Discovery (C.W.L.), Vanderbilt University Medical Center; Department of Chemistry, Vanderbilt Institute of Chemical Biology (C.W.L., H.A.B.); Vanderbilt Specialized Chemistry for Accelerated Probe Development (C.W.L.); and Department of Biochemistry, Vanderbilt-Ingram Cancer Center (H.A.B.), Vanderbilt University, Nashville, Tennessee
Roles: ASSOCIATE EDITOR

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In this issue
Review ArticleReview Article
PLD and Phosphatidic Acid in Cancer
Ronald C. Bruntz, Craig W. Lindsley and H. Alex Brown
Pharmacological Reviews October 1, 2014, 66 (4) 1033-1079; DOI: https://doi.org/10.1124/pr.114.009217
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- Article
- Abstract
- I. Background
- II. Regulation of Phospholipase D Activity by Lipids
- III. Phosphorylation
- IV. Protein Activators of Phospholipase D
- V. Phospholipase D Inhibitory Proteins
- VI. Cell Surface Receptor Regulation of Phospholipase D
- VII. Functions of Phospholipase D Contributing to Cancer
- VIII. Phospholipase D Small-Molecule Inhibitors
- IX. Functions of Phosphatidic Acid
- X. Closing Points
- Acknowledgments
- Authorship Contributions
- Footnotes
- Abbreviations
- References
- Figures & Data
- Info & Metrics
- eLetters
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