Review ArticleReview Article
The Rho Kinases: Critical Mediators of Multiple Profibrotic Processes and Rational Targets for New Therapies for Pulmonary Fibrosis
Rachel S. Knipe, Andrew M. Tager and James K. Liao
Yoshihiro Ishikawa, ASSOCIATE EDITOR
Pharmacological Reviews January 2015, 67 (1) 103-117; DOI: https://doi.org/10.1124/pr.114.009381
Rachel S. Knipe
Pulmonary and Critical Care Unit and Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts (R.S.K., A.M.T.); and Section of Cardiology, Department of Medicine, University of Chicago, Chicago, Illinois (J.K.L.)
Andrew M. Tager
Pulmonary and Critical Care Unit and Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts (R.S.K., A.M.T.); and Section of Cardiology, Department of Medicine, University of Chicago, Chicago, Illinois (J.K.L.)
James K. Liao
Pulmonary and Critical Care Unit and Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts (R.S.K., A.M.T.); and Section of Cardiology, Department of Medicine, University of Chicago, Chicago, Illinois (J.K.L.)
Yoshihiro Ishikawa
Pulmonary and Critical Care Unit and Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts (R.S.K., A.M.T.); and Section of Cardiology, Department of Medicine, University of Chicago, Chicago, Illinois (J.K.L.)
Roles: ASSOCIATE EDITOR
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In this issue
Review ArticleReview Article
Rho Kinases in Pulmonary Fibrosis
Rachel S. Knipe, Andrew M. Tager and James K. Liao
Pharmacological Reviews January 1, 2015, 67 (1) 103-117; DOI: https://doi.org/10.1124/pr.114.009381
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- Article
- Abstract
- I. Introduction
- II. Rho-Associated Coiled-Coil Forming Protein Kinase Structure and Function
- III. Upstream Activators and Downstream Targets of Rho-Associated Coiled-Coil Forming Protein Kinases in Pulmonary Fibrosis
- IV. Contributions of Rho-Associated Coiled-Coil Forming Protein Kinases to Profibrotic Cellular Responses to Lung Injury
- V. Rho-Associated Coiled-Coil Forming Protein Kinase Inhibitors and Their Efficacy in Animal Models of Pulmonary Fibrosis
- VI. Involvement of Rho-Associated Coiled-Coil Forming Protein Kinase Inhibitors in Fibrosis in Other Organs
- VII. Potential Toxicities of Rho-Associated Coiled-Coil Forming Protein Kinase Inhibitors in Humans
- VIII. Conclusions
- Authorship Contributions
- Footnotes
- Abbreviations
- References
- Figures & Data
- Info & Metrics
- eLetters
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