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Review ArticleReview Article

Serotonin 5-HT2 Receptor Interactions with Dopamine Function: Implications for Therapeutics in Cocaine Use Disorder

Leonard L. Howell and Kathryn A. Cunningham
Michael A. Nader, ASSOCIATE EDITOR
Pharmacological Reviews January 2015, 67 (1) 176-197; DOI: https://doi.org/10.1124/pr.114.009514
Leonard L. Howell
Yerkes National Primate Research Center, Emory University, Atlanta, Georgia (L.L.H.); and Center for Addiction Research and Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, Texas (K.A.C.)
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Kathryn A. Cunningham
Yerkes National Primate Research Center, Emory University, Atlanta, Georgia (L.L.H.); and Center for Addiction Research and Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, Texas (K.A.C.)
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Michael A. Nader
Yerkes National Primate Research Center, Emory University, Atlanta, Georgia (L.L.H.); and Center for Addiction Research and Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, Texas (K.A.C.)
Roles: ASSOCIATE EDITOR
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Pharmacological Reviews: 67 (1)
Pharmacological Reviews
Vol. 67, Issue 1
1 Jan 2015
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Review ArticleReview Article

Cocaine, 5-HT2 Receptors, and Dopamine

Leonard L. Howell and Kathryn A. Cunningham
Pharmacological Reviews January 1, 2015, 67 (1) 176-197; DOI: https://doi.org/10.1124/pr.114.009514

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Review ArticleReview Article

Cocaine, 5-HT2 Receptors, and Dopamine

Leonard L. Howell and Kathryn A. Cunningham
Pharmacological Reviews January 1, 2015, 67 (1) 176-197; DOI: https://doi.org/10.1124/pr.114.009514
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  • Article
    • Abstract
    • I. Introduction
    • II. Neuroscience of Cocaine Use Disorder
    • III. Serotonin Neurotransmission
    • IV. 5-HT2 Receptor Regulation of Dopamine Neurotransmission
    • V. Cortical Dysregulation and 5-HT2A/C Receptor Function
    • VI. Targeted 5-HT2A/C Receptor Pharmacotherapy for Cocaine Addiction
    • VII. Conclusion
    • Acknowledgments
    • Authorship Contributions
    • Footnotes
    • Abbreviations
    • References
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