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OtherIUPHAR Nomenclature Reports

International Union of Basic and Clinical Pharmacology. XCIII. The Parathyroid Hormone Receptors—Family B G Protein–Coupled Receptors

Thomas J. Gardella and Jean-Pierre Vilardaga
Eliot H. Ohlstein, ASSOCIATE EDITOR
Pharmacological Reviews April 2015, 67 (2) 310-337; DOI: https://doi.org/10.1124/pr.114.009464
Thomas J. Gardella
Endocrine Unit, Massachusetts General Hospital, Boston, Massachusetts (T.J.G.); and Laboratory for GPCR Biology, Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania (J.-P.V.)
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Jean-Pierre Vilardaga
Endocrine Unit, Massachusetts General Hospital, Boston, Massachusetts (T.J.G.); and Laboratory for GPCR Biology, Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania (J.-P.V.)
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Eliot H. Ohlstein
Endocrine Unit, Massachusetts General Hospital, Boston, Massachusetts (T.J.G.); and Laboratory for GPCR Biology, Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania (J.-P.V.)
Roles: ASSOCIATE EDITOR
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Article Information

vol. 67 no. 2 310-337
DOI 
https://doi.org/10.1124/pr.114.009464
PubMed 
25713287

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0031-6997
Online ISSN 
1521-0081
History 
  • Published online February 23, 2015.

Copyright & Usage 
Copyright © 2015 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Thomas J. Gardella and
  2. Jean-Pierre Vilardaga
  1. Endocrine Unit, Massachusetts General Hospital, Boston, Massachusetts (T.J.G.); and Laboratory for GPCR Biology, Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania (J.-P.V.)
  1. Eliot H. Ohlstein, ASSOCIATE EDITOR
  1. Address correspondence to:
    Dr. Thomas J. Gardella, Endocrine Unit, Massachusetts General Hospital, Thier 10, 50 Blossom St., Boston, MA 02114. E-mail: Gardella{at}Helix.MGH.Harvard.edu
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Pharmacological Reviews: 67 (2)
Pharmacological Reviews
Vol. 67, Issue 2
1 Apr 2015
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OtherIUPHAR Nomenclature Reports

Parathyroid Hormone Receptors and Their Ligands

Thomas J. Gardella and Jean-Pierre Vilardaga
Pharmacological Reviews April 1, 2015, 67 (2) 310-337; DOI: https://doi.org/10.1124/pr.114.009464

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OtherIUPHAR Nomenclature Reports

Parathyroid Hormone Receptors and Their Ligands

Thomas J. Gardella and Jean-Pierre Vilardaga
Pharmacological Reviews April 1, 2015, 67 (2) 310-337; DOI: https://doi.org/10.1124/pr.114.009464
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  • Article
    • Abstract
    • I. Introduction
    • II. Biologic Actions at the Type-1 Parathyroid Hormone Receptor In Vivo
    • III. Structure-Activity Relationships in Parathyroid Hormone and Parathyroid Hormone–Related Protein Ligands
    • IV. The Type-1 Hormone Receptor Gene Identification, Classification, and Structure
    • V. The Parathyroid Hormone-2 Receptor and Tuberoinfundibular Peptide-39
    • VI. Evolution of Parathyroid Hormone Receptors and Their Ligands
    • VII. Structural Features of the Type-1 Parathyroid Hormone Receptor and Mode of Ligand Binding
    • VIII. Mechanisms of Signal Transduction
    • IX. Type-1 Parathyroid Hormone Receptor Mutations in Human Disease
    • X. Small-Molecule Ligands for the Type-1 Parathyroid Hormone Receptor
    • XI. Concluding Remarks
    • Acknowledgments
    • Authorship Contributions
    • Footnotes
    • Abbreviations
    • References
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