OtherIUPHAR Nomenclature Reports
International Union of Basic and Clinical Pharmacology. XCIII. The Parathyroid Hormone Receptors—Family B G Protein–Coupled Receptors
Thomas J. Gardella and Jean-Pierre Vilardaga
Eliot H. Ohlstein, ASSOCIATE EDITOR
Pharmacological Reviews April 2015, 67 (2) 310-337; DOI: https://doi.org/10.1124/pr.114.009464
Thomas J. Gardella
Endocrine Unit, Massachusetts General Hospital, Boston, Massachusetts (T.J.G.); and Laboratory for GPCR Biology, Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania (J.-P.V.)
Jean-Pierre Vilardaga
Endocrine Unit, Massachusetts General Hospital, Boston, Massachusetts (T.J.G.); and Laboratory for GPCR Biology, Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania (J.-P.V.)
Eliot H. Ohlstein
Endocrine Unit, Massachusetts General Hospital, Boston, Massachusetts (T.J.G.); and Laboratory for GPCR Biology, Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania (J.-P.V.)
Roles: ASSOCIATE EDITOR
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In this issue
OtherIUPHAR Nomenclature Reports
Parathyroid Hormone Receptors and Their Ligands
Thomas J. Gardella and Jean-Pierre Vilardaga
Pharmacological Reviews April 1, 2015, 67 (2) 310-337; DOI: https://doi.org/10.1124/pr.114.009464
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- Article
- Abstract
- I. Introduction
- II. Biologic Actions at the Type-1 Parathyroid Hormone Receptor In Vivo
- III. Structure-Activity Relationships in Parathyroid Hormone and Parathyroid Hormone–Related Protein Ligands
- IV. The Type-1 Hormone Receptor Gene Identification, Classification, and Structure
- V. The Parathyroid Hormone-2 Receptor and Tuberoinfundibular Peptide-39
- VI. Evolution of Parathyroid Hormone Receptors and Their Ligands
- VII. Structural Features of the Type-1 Parathyroid Hormone Receptor and Mode of Ligand Binding
- VIII. Mechanisms of Signal Transduction
- IX. Type-1 Parathyroid Hormone Receptor Mutations in Human Disease
- X. Small-Molecule Ligands for the Type-1 Parathyroid Hormone Receptor
- XI. Concluding Remarks
- Acknowledgments
- Authorship Contributions
- Footnotes
- Abbreviations
- References
- Figures & Data
- Info & Metrics
- eLetters
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